Synthesis and SAR study of diphenylbutylpiperidines as cell autophagy inducers

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	Synthesis and SAR study of diphenylbutylpiperidines as cell autophagy inducers
	Chen G(陈刚) ; Xia HG(夏宏光) ; Cai Y(蔡俞) ; Ma DW(马大为) ; Yuan JY(袁钧瑛) ; Yuan CY(袁承业)
刊名	Bioorg. Med. Chem. Lett.
	2011
卷号	21 期号:1 页码:234-239
其他题名	细胞自吞噬诱导剂二苯基丁基哌啶的合成及构效关系研究
英文摘要	A novel series of diphenylbutylpiperidines as autophagy inducers was described and extensive SAR studies resulted in derivatives (15d-e, 15i-j) with 10-fold greater activity than the lead compounds 1 and 2. Meanwhile, a new synthetic route to diphenylbutyl bromide (6) from bromobenzene and gamma-butyrolactone was also reported here. (C) 2010 Elsevier Ltd. All rights reserved.
学科主题	生命有机化学
收录类别	SCI
原文出处	http://dx.doi.org/10.1016/j.bmcl.2010.11.029
语种	英语
WOS记录号	WOS:000285544400045
公开日期	2013-01-09
内容类型	期刊论文
源URL	[http://202.127.28.38/handle/331003/11086]
专题	上海有机化学研究所_上海有机化学研究所
推荐引用方式 GB/T 7714	Chen G,Xia HG,Cai Y,et al. Synthesis and SAR study of diphenylbutylpiperidines as cell autophagy inducers[J]. Bioorg. Med. Chem. Lett.,2011,21(1):234-239.
APA	Chen G,Xia HG,Cai Y,Ma DW,Yuan JY,&Yuan CY.(2011).Synthesis and SAR study of diphenylbutylpiperidines as cell autophagy inducers.Bioorg. Med. Chem. Lett.,21(1),234-239.
MLA	Chen G,et al."Synthesis and SAR study of diphenylbutylpiperidines as cell autophagy inducers".Bioorg. Med. Chem. Lett. 21.1(2011):234-239.