Chemical Constituents from Chirita longgangensis var. hongyao with Inhibitory Activity against Porcine Respiratory and Reproductive Syndrome Virus

CORC > 昆明植物研究所 > 中国科学院昆明植物研究所 > 资源植物与生物技术所级重点实验室

	Chemical Constituents from Chirita longgangensis var. hongyao with Inhibitory Activity against Porcine Respiratory and Reproductive Syndrome Virus
	Su, Yao 2,3; Bi, Jun-Long 1; Wang, Yue-Hu3 ; Tan, Ying 3; Yang, Jun 2,3; Liu, Hong-Xin 3; Gu, Wei3 ; Yin, Ge-Fen 1; Long, Chun-Lin 3,4
刊名	JOURNAL OF THE BRAZILIAN CHEMICAL SOCIETY
	2012-10-01
卷号	23 期号:10 页码:1925-1932
关键词	Gesneriaceae quinines porcine reproductive and respiratory syndrome virus Chirita longgangensis var. hongyao
ISSN号	0103-5053
通讯作者	Yin, GF (reprint author), Yunnan Agr Univ, Coll Anim Sci & Technol, Kunming 650201, Peoples R China.,yingefen383@sohu.com ; long@mail.kib.ac.cn
英文摘要	Two new quinonoids chiritalone A and B, and a new neolignan 7'E-4,9-dihydroxy3,3',5'-trimethoxy-8,4'-oxyneolign-7'-en-9'-al, along with known (-)-8-hydroxy-alpha-dunnione, digiferruginol, 2,5-dimethoxy-1,4-benzoquinone and hederagenin, were isolated from the stems of Chirita longgangensis var. hongyao. The structures of the new compounds were elucidated by detailed analysis from NMR (nuclear magnetic resonance) and MS (mass spectrometry) data, and the absolute configuration of chiritalone A was determined by single crystal X-ray diffraction analysis using the Flack parameter. The inhibitory activity of compounds against porcine respiratory and reproductive syndrome virus (PRRSV) was measured by the cytopathic effect (CPE) method. Digiferruginol and hederagenin showed weak effect on PRRSV with an IC50 value of 80.5 +/- 16.9 mu mol L-1 (SI = 19.9) and 43.2 +/- 7.4 mu mol L-1 (SI = 13.1), respectively.
学科主题	Chemistry, Multidisciplinary
类目[WOS]	Chemistry, Multidisciplinary
研究领域[WOS]	Chemistry
关键词[WOS]	CYTOTOXIC ANTHRAQUINONES ; TETRAZOLIUM SALT ; QUINONES ; NAPHTHOQUINONES ; REPLICATION ; EBURNEA ; AGENTS ; ROOTS ; ACID
收录类别	SCI ; IC
资助信息	National Natural Science Foundation of China [31070288, 20972166, 31160509, 31161140345]; Yunnan Provincial Program for Excellent Scientists [2009CI125]; Key Research Direction Project of Knowledge Innovation Program for Chinese Academy of Sciences [KSCX2-EW-J-24]; Ministry of Education of China [B08044, MUC985-9, MUC98506-01000101]
语种	英语
WOS记录号	WOS:000312199200023
公开日期	2013-01-22
内容类型	期刊论文
源URL	[http://ir.kib.ac.cn/handle/151853/15996]
专题	昆明植物研究所_资源植物与生物技术所级重点实验室
作者单位	1.Yunnan Agr Univ, Coll Anim Sci & Technol, Kunming 650201, Peoples R China 2.Yunnan Agr Univ, Sch Agron & Biotechnol, Kunming 650201, Peoples R China 3.Chinese Acad Sci, Kunming Inst Bot, Key Lab Econ Plants & Biotechnol, Kunming 650201, Peoples R China 4.Minzu Univ China, Coll Life & Environm Sci, Beijing 100081, Peoples R China
推荐引用方式 GB/T 7714	Su, Yao,Bi, Jun-Long,Wang, Yue-Hu,et al. Chemical Constituents from Chirita longgangensis var. hongyao with Inhibitory Activity against Porcine Respiratory and Reproductive Syndrome Virus[J]. JOURNAL OF THE BRAZILIAN CHEMICAL SOCIETY,2012,23(10):1925-1932.
APA	Su, Yao.,Bi, Jun-Long.,Wang, Yue-Hu.,Tan, Ying.,Yang, Jun.,...&Long, Chun-Lin.(2012).Chemical Constituents from Chirita longgangensis var. hongyao with Inhibitory Activity against Porcine Respiratory and Reproductive Syndrome Virus.JOURNAL OF THE BRAZILIAN CHEMICAL SOCIETY,23(10),1925-1932.
MLA	Su, Yao,et al."Chemical Constituents from Chirita longgangensis var. hongyao with Inhibitory Activity against Porcine Respiratory and Reproductive Syndrome Virus".JOURNAL OF THE BRAZILIAN CHEMICAL SOCIETY 23.10(2012):1925-1932.