The Caenorhabditis elegans intermediate-size transcriptome shows high degree of stage-specific expression

doi:10.1093/nar/gkr102

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	The Caenorhabditis elegans intermediate-size transcriptome shows high degree of stage-specific expression
	Wang, Yunfei 2,3,4; Chen, Jingjing 2,3,4; Wei, Guifeng 2,3,4; He, Housheng 2,3,5; Zhu, Xiaopeng 2,3; Xiao, Tengfei 2,3,4; Yuan, Jiao 2,3,4; Dong, Bo 2,3,4; He, Shunmin 2,3,6; Skogerbo, Geir 2,3
刊名	NUCLEIC ACIDS RESEARCH
	2011-07-01
卷号	39 期号:12 页码:5203-5214
ISSN号	0305-1048
DOI	10.1093/nar/gkr102
英文摘要	Earlier studies have revealed a substantial amount of transcriptional activity occurring outside annotated protein-coding genes of the Caenorhabditis elegans genome. One important fraction of this transcriptional activity relates to intermediate-size (70-500 nt) transcripts (is-ncRNAs) of mostly unknown function. Profiling the expression of this segment of the transcriptome on a tiling array through the C. elegans life cycle identified 5866 hitherto unannotated transcripts. The novel loci were distributed across intronic and intergenic space, with some enrichment toward protein-coding gene termini. The majority of the putative is-ncRNAs showed either stage-specific expression, or distinct developmental variation in their expression levels. More than 200 loci showed male-specific expression, and conserved loci were significantly enriched on the X chromosome, both observations strongly suggesting involvement of is-ncRNAs in sex-specific functions. Half of the novel loci were conserved in other nematodes, and numerous loci showed significant conservational correlations to nearby coding genes. Assuming functional roles for most of the novel loci, the data imply a nematode is-ncRNA tool kit of considerable size and variety.
资助项目	National Institutes of Health-National Center for Research Resources ; National Sciences Foundation of China[30630040] ; National Key Basic Research and Development Program 973[2009CB825400] ; National Key Basic Research and Development Program 973[2007CB946901] ; National Key Basic Research and Development Program 973[2007CB935703]
WOS研究方向	Biochemistry & Molecular Biology
语种	英语
出版者	OXFORD UNIV PRESS
WOS记录号	WOS:000292564900033
内容类型	期刊论文
源URL	[http://119.78.100.204/handle/2XEOYT63/12925]
专题	中国科学院计算技术研究所期刊论文_英文
通讯作者	Skogerbo, Geir
作者单位	1.Chinese Natl Human Genome Ctr, Beijing 100176, Peoples R China 2.Chinese Acad Sci, Bioinformat Lab, Beijing 100101, Peoples R China 3.Chinese Acad Sci, Natl Lab Biomacromol, Inst Biophys, Beijing 100101, Peoples R China 4.Chinese Acad Sci, Grad Sch, Beijing 100080, Peoples R China 5.Harvard Univ, Sch Publ Hlth, Dana Farber Canc Inst, Dept Biostat & Computat Biol, Boston, MA 02115 USA 6.Chinese Acad Sci, Inst Zool, Key Lab Zool Syst & Evolut, Beijing 100101, Peoples R China 7.Chinese Acad Sci, Inst Comp Technol, Bioinformat Res Grp, Key Lab Intelligent Informat Proc, Beijing 100080, Peoples R China
推荐引用方式 GB/T 7714	Wang, Yunfei,Chen, Jingjing,Wei, Guifeng,et al. The Caenorhabditis elegans intermediate-size transcriptome shows high degree of stage-specific expression[J]. NUCLEIC ACIDS RESEARCH,2011,39(12):5203-5214.
APA	Wang, Yunfei.,Chen, Jingjing.,Wei, Guifeng.,He, Housheng.,Zhu, Xiaopeng.,...&Chen, Runsheng.(2011).The Caenorhabditis elegans intermediate-size transcriptome shows high degree of stage-specific expression.NUCLEIC ACIDS RESEARCH,39(12),5203-5214.
MLA	Wang, Yunfei,et al."The Caenorhabditis elegans intermediate-size transcriptome shows high degree of stage-specific expression".NUCLEIC ACIDS RESEARCH 39.12(2011):5203-5214.