Several microRNAs could predict survival in patients with hepatitis B-related liver cancer

doi:10.1038/srep45195

CORC > 计算技术研究所 > 中国科学院计算技术研究所 > 中国科学院计算技术研究所期刊论文 > 英文

	Several microRNAs could predict survival in patients with hepatitis B-related liver cancer
	Ye Zhen 1,2,3; Zhao Xinghui 4; Wu Chao 1; Zhao Yi 5; Chen Jinwen 5; Gao Ruifang 1; Zhang Chao 6; Zhao Min 3; Guo Chunlei 1; Fang Yan 1
刊名	SCIENTIFIC REPORTS
	2017-03-21
卷号	7 页码:8
ISSN号	2045-2322
DOI	10.1038/srep45195
英文摘要	MicroRNAs as biomarkers play an important role in the tumorigenesis process, including hepatocellular carcinomas (HCCs). In this paper, we used The Cancer Genome Atlas (TCGA) database to mine hepatitis B-related liver cancer microRNAs that could predict survival in patients with hepatitis B-related liver cancer. There were 93 cases of HBV-HCC and 49 cases of adjacent normal controls included in the study. Kaplan-Meier survival analysis of a liver cancer group versus a normal control group of differentially expressed genes identified eight genes with statistical significance. Compared with the normal liver cell line, hepatocellular carcinoma cell lines had high expression of 8 microRNAs, albeit at different levels. A Cox proportional hazards regression model for multivariate analysis showed that four genes had a significant difference. We established classification models to distinguish short survival time and long survival time of liver cancers. Eight genes (mir9-3, mir10b, mir31, mir519c, mir522, mir3660, mir4784, and mir6883) were identified could predict survival in patients with HBV-HCC. There was a significant correlation between mir10b and mir31 and clinical stages (p < 0.05). A random forests model effectively estimated patient survival times.
资助项目	National Basic Research Program of China 973 Program[2013CB967201]
WOS研究方向	Science & Technology - Other Topics
语种	英语
出版者	NATURE PUBLISHING GROUP
WOS记录号	WOS:000396852900001
内容类型	期刊论文
源URL	[http://119.78.100.204/handle/2XEOYT63/7325]
专题	中国科学院计算技术研究所期刊论文_英文
通讯作者	Xiang Rong
作者单位	1.Nankai Univ, Sch Med, Dept Tumor Mol Biol, Tianjin 371000, Peoples R China 2.Taishan Med Univ, Sch Publ Hlth, Tai An 271016, Shandong, Peoples R China 3.Taian Cent Hosp, Dept Infect Dis, Tai An 271000, Shandong, Peoples R China 4.Beijing Inst Technol, Lab Vaccine & Antibody Engn, Beijing 100071, Peoples R China 5.Chinese Acad Sci, Inst Comp Technol, Key Lab Intelligent Informat Proc, Beijing 100190, Peoples R China 6.Shandong Agr Univ, Coll Informat Sci & Engn, Tai An 271000, Shandong, Peoples R China 7.Nankai Univ, Sch Med, 2011 Project Collaborat Innovat Ctr Biol Therapy, Tianjin 371000, Peoples R China 8.Nankai Univ, Sch Med, Minist Educ, Int Collaborat Lab Biol Med, Tianjin 371000, Peoples R China
推荐引用方式 GB/T 7714	Ye Zhen,Zhao Xinghui,Wu Chao,et al. Several microRNAs could predict survival in patients with hepatitis B-related liver cancer[J]. SCIENTIFIC REPORTS,2017,7:8.
APA	Ye Zhen.,Zhao Xinghui.,Wu Chao.,Zhao Yi.,Chen Jinwen.,...&Xiang Rong.(2017).Several microRNAs could predict survival in patients with hepatitis B-related liver cancer.SCIENTIFIC REPORTS,7,8.
MLA	Ye Zhen,et al."Several microRNAs could predict survival in patients with hepatitis B-related liver cancer".SCIENTIFIC REPORTS 7(2017):8.