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	Method and system for examining biological materials using low power CW excitation raman spectroscopy
	ALFANO, ROBERT R.; WANG, WUBAO
	2000-11-21
著作权人	RESEARCH FOUNDATION OF CUNY, THE
专利号	US6151522
国家	美国
文献子类	授权发明
其他题名	Method and system for examining biological materials using low power CW excitation raman spectroscopy
英文摘要	A method and system for examining biological materials using low-power cw excitation Raman spectroscopy. In accordance with the teachings of the invention, a low-power continuous wave (cw) pump laser beam and a low-power cw Stokes (or anti-Stokes) probe laser beam simultaneously illuminate a biological material and traverse the biological material in collinearity. The pump beam, whose frequency is varied, is used to induce Raman emission from the biological material. The intensity of the probe beam, whose frequency is kept constant, is monitored as it leaves the biological material. When the difference between the pump and probe excitation frequencies is equal to a Raman vibrational mode frequency of the biological material, the weak probe signal becomes amplified by one or more orders of magnitude (typically up to about 104-106) due to the Raman emission from the pump beam. In this manner, by monitoring the intensity of the probe beam emitted from the biological material as the pump beam is varied in frequency, one can obtain an excitation Raman spectrum for the biological material tested. The present invention may be applied to in the in vivo and/or in vitro diagnosis of diabetes, heart disease, hepatitis, cancers and other diseases by measuring the characteristic excitation Raman lines of blood glucose, cholesterol, serum glutamic oxalacetic transaminase (SGOT)/serum glutamic pyruvic tansaminase (SGPT), tissues and other corresponding Raman-active body constituents, respectively. For example, it may also be used to diagnose diseases associated with the concentration of Raman-active constituents in urine, lymph and saliva It may be used to identify cancer in the breast, cervix, uterus, ovaries and the like by measuring the fingerprint excitation Raman spectra of these tissues. It may also be used to reveal the growing of tumors or cancers by measuring the levels of nitric oxide in tissue.
公开日期	2000-11-21
申请日期	1999-03-16
状态	失效
内容类型	专利
源URL	[http://ir.opt.ac.cn/handle/181661/34467]
专题	半导体激光器专利数据库
作者单位	RESEARCH FOUNDATION OF CUNY, THE
推荐引用方式 GB/T 7714	ALFANO, ROBERT R.,WANG, WUBAO. Method and system for examining biological materials using low power CW excitation raman spectroscopy. US6151522. 2000-11-21.

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