One-Pot Synthesis of 3-Substituted-4(3H)-quinazolinones in Acidic Ionic Liquids under Microwave Irradiation Conditions

CORC > 新疆理化技术研究所 > 中国科学院新疆理化技术研究所 > 新疆维吾尔自治区精细化工工程技术研究中心

	One-Pot Synthesis of 3-Substituted-4(3H)-quinazolinones in Acidic Ionic Liquids under Microwave Irradiation Conditions
	Li Xinzhong; Lin Qi; Eli Wumanjiang
刊名	CHINESE JOURNAL OF ORGANIC CHEMISTRY
	2011
卷号	31 期号:6 页码:855-859
关键词	Bronsted acid ionic liquid multi-component
ISSN号	0253-2786
英文摘要	Two novel Bronsted acidic ionic liquids 1-(4-sulfonic)-benzyl-3-methylimidazolium hydrogen sulfate (a) and 1-(4-sulfonic)-benzyl-3-methylpyridium hydrogen sulfate (b) were used as catalyst and medium in the one-pot synthesis of 3-substituted-4(3H)-quinazolinones, using anthranilic acid, triethyl orthoformate or formic acid and aromatic or aliphatic amines as starting materials under microwave irradiation. It was found that the reactions completed within 4 similar to 6 min with good to excellent yields (74 similar to 94%) in the presence of 10 mol% ionic liquids. The ionic liquids can be recovered easily and recycled three times without any significant loss in catalytic activity. This synthetic method has the advantage of generality. The aromatic or aliphatic substituents can be introduced in the 3-position, the substrates with electron-withdrawing substituents can also take part of the reaction smoothly and offered satisfactory yields. In addition to, this synthetic method can use 85% formic acid directly with yields of 72%similar to 91%.
学科主题	Chemistry
收录类别	SCI
WOS记录号	WOS:000292582000012
公开日期	2012-11-29
内容类型	期刊论文
源URL	[http://ir.xjipc.cas.cn/handle/365002/1660]
专题	新疆理化技术研究所_新疆维吾尔自治区精细化工工程技术研究中心
作者单位	Minjiang Univ, Dept Chem & Chem Engn, Fuzhou 350108, Peoples R China;Chinese Acad Sci, Xinjiang Tech Inst Phys & Chem, Urumqi 830011, Peoples R China
推荐引用方式 GB/T 7714	Li Xinzhong,Lin Qi,Eli Wumanjiang. One-Pot Synthesis of 3-Substituted-4(3H)-quinazolinones in Acidic Ionic Liquids under Microwave Irradiation Conditions[J]. CHINESE JOURNAL OF ORGANIC CHEMISTRY,2011,31(6):855-859.
APA	Li Xinzhong,Lin Qi,&Eli Wumanjiang.(2011).One-Pot Synthesis of 3-Substituted-4(3H)-quinazolinones in Acidic Ionic Liquids under Microwave Irradiation Conditions.CHINESE JOURNAL OF ORGANIC CHEMISTRY,31(6),855-859.
MLA	Li Xinzhong,et al."One-Pot Synthesis of 3-Substituted-4(3H)-quinazolinones in Acidic Ionic Liquids under Microwave Irradiation Conditions".CHINESE JOURNAL OF ORGANIC CHEMISTRY 31.6(2011):855-859.