Synthesis of Novel Isoxazole Contained Rupestonic Acid Derivatives and in vitro Inhibitory Activity against Influenza Viruses A and B | |
Zhao Jiangyu; Aisa Haji Akber | |
刊名 | CHINESE JOURNAL OF ORGANIC CHEMISTRY |
2012 | |
卷号 | 32期号:2页码:333-337 |
关键词 | rupestonic acid isoxazole derivative influenza virus inhibitory activity |
ISSN号 | 0253-2786 |
通讯作者 | Zhao, JY |
英文摘要 | To improve biological activity of rupestonic acid, six rupestonic acid amide derivatives containing isoxazole were synthesized in the presence of DCC, HOBt/DMAP using the rupestonic acid and 3-aryl-5-isoxazole-methylamine as the starting materials. The synthesized compounds 3a similar to 3f were confirmed by the methods of H-1 NMR, C-13 NMR, IR, ESI-MS techniques and preliminarily assayed in vitro against influenza viruses A and B. The results showed that compound 3c showed better activity against both influenza viruses A (H3N2) and B, and compounds 3c and 3e had the higher inhibition against influenza B virus than the parent compound 1. |
学科主题 | Chemistry |
收录类别 | SCI |
WOS记录号 | WOS:000301616200011 |
公开日期 | 2012-11-29 |
内容类型 | 期刊论文 |
源URL | [http://ir.xjipc.cas.cn/handle/365002/1641] |
专题 | 新疆理化技术研究所_省部共建新疆特有药用资源利用重点实验室 |
作者单位 | Chinese Acad Sci, Xinjiang Tech Inst Phys & Chem, Key Lab Chem Plant Resources Arid Reg, Urumqi 830011, Peoples R China;Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China |
推荐引用方式 GB/T 7714 | Zhao Jiangyu,Aisa Haji Akber. Synthesis of Novel Isoxazole Contained Rupestonic Acid Derivatives and in vitro Inhibitory Activity against Influenza Viruses A and B[J]. CHINESE JOURNAL OF ORGANIC CHEMISTRY,2012,32(2):333-337. |
APA | Zhao Jiangyu,&Aisa Haji Akber.(2012).Synthesis of Novel Isoxazole Contained Rupestonic Acid Derivatives and in vitro Inhibitory Activity against Influenza Viruses A and B.CHINESE JOURNAL OF ORGANIC CHEMISTRY,32(2),333-337. |
MLA | Zhao Jiangyu,et al."Synthesis of Novel Isoxazole Contained Rupestonic Acid Derivatives and in vitro Inhibitory Activity against Influenza Viruses A and B".CHINESE JOURNAL OF ORGANIC CHEMISTRY 32.2(2012):333-337. |
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