Lipase-catalysed kinetic resolution of secondary alcohols with improved enantioselectivity in propylene carbonate

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	Lipase-catalysed kinetic resolution of secondary alcohols with improved enantioselectivity in propylene carbonate
	Sun W(孙伟); Xia CG(夏春谷); Sun W(孙伟)
刊名	World Journal of Microbiology & Biotechnology
	2008
卷号	24 页码:2421-2424
关键词	Candida antarctica lipase Enantioselectivity Propylene carbonate Triethylamine Vinyl acetate
ISSN号	0959-3993
通讯作者	夏春谷 ; 孙伟
中文摘要	The lipase-catalysed kinetic resolution of secondary alcohols was studied using vinyl acetate as acyl donor in propylene carbonate. Propylene carbonate offers an environmentally friendly alternative in contrast to conventional solvents. Several different lipases were investigated, and Candida antarctica lipase B (CALB) exhibited better results for all the substrates. It was shown that the addition of non-reactive base triethylamine and silver oxide to the reaction mixture enhanced the reaction rate and enantioselectivity. With propylene carbonate as solvent, CALB could be recycled without significant activity or enantioselectivity losses.
学科主题	清洁催化与生物转化
收录类别	SCI
资助信息	the NSFC (20625308;20643008);Chinese Academy of Sciences
语种	英语
WOS记录号	WOS:000259444500008
公开日期	2012-11-30
内容类型	期刊论文
源URL	[http://210.77.64.217/handle/362003/2278]
专题	兰州化学物理研究所_OSSO国家重点实验室
通讯作者	Sun W(孙伟); Xia CG(夏春谷); Sun W(孙伟)
推荐引用方式 GB/T 7714	Sun W,Xia CG,Sun W. Lipase-catalysed kinetic resolution of secondary alcohols with improved enantioselectivity in propylene carbonate[J]. World Journal of Microbiology & Biotechnology,2008,24:2421-2424.
APA	孙伟,夏春谷,&孙伟.(2008).Lipase-catalysed kinetic resolution of secondary alcohols with improved enantioselectivity in propylene carbonate.World Journal of Microbiology & Biotechnology,24,2421-2424.
MLA	孙伟,et al."Lipase-catalysed kinetic resolution of secondary alcohols with improved enantioselectivity in propylene carbonate".World Journal of Microbiology & Biotechnology 24(2008):2421-2424.