Pavidolides A-E, new cembranoids from the soft coral Sinularia pavida

CORC > 昆明植物研究所 > 中国科学院昆明植物研究所 > 植物化学与西部植物资源持续利用国家重点实验室

	Pavidolides A-E, new cembranoids from the soft coral Sinularia pavida
	Shen, Shi 1; Zhu, Huajie 2; Chen, Dawei 1; Liu, Dong 1; van Ofwegen, Leen 3; Proksch, Peter 4; Lin, Wenhan 1
刊名	TETRAHEDRON LETTERS
	2012-10-24
卷号	53 期号:43 页码:5759-5762
关键词	Soft coral Sinularia pavida Pavidolides A-E Structural elucidation Antifouling activity Cytotoxic activity
ISSN号	0040-4039
通讯作者	Lin, WH (reprint author), Peking Univ, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China.,whlin@bjmu.edu.cn
英文摘要	Five new cembrane-based diterpenoids, namely pavidolides A-E (1-5) were isolated from the marine soft coral Sinularia pavida, together with sarcophytin and chatancin. The structures of new compounds were determined on the basis of extensive spectroscopic data analysis. Pavidolide B (2) possesses an unprecedented 6,5,7-tricarbocyclic nucleus, whereas pavidolide C (3) is characteristic of an unusual C-5 and C-9 conjuncted cembranoid. Pavidolides C and D showed moderate antifouling activity against the larval settlement of barnacle Balanus amphitrite, while pavidolides B and C exhibited inhibitory activity against the human leukemia cell line HL-60. (C) 2012 Elsevier Ltd. All rights reserved.
类目[WOS]	Chemistry, Organic
研究领域[WOS]	Chemistry
关键词[WOS]	COELENTERATA ; OCTOCORALLIA ; CHEMISTRY ; DFT
收录类别	SCI ; IC
资助信息	NSFC [30930109]; National Innovation Project [2009ZX09501-014, 2009ZX09103-140]; CMST Projects [2010DFA31610]
语种	英语
WOS记录号	WOS:000309618000010
公开日期	2012-11-30
内容类型	期刊论文
源URL	[http://ir.kib.ac.cn/handle/151853/15690]
专题	昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室
作者单位	1.Peking Univ, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China 2.Chinese Acad Sci, Kunming Inst Bot, Kunming 650204, Peoples R China 3.Natl Museum Nat Hist Nat, NL-2300 RA Leiden, Netherlands 4.Univ Dusseldorf, Inst Pharmaceut Biol & Biotechnol, D-40225 Dusseldorf, Germany
推荐引用方式 GB/T 7714	Shen, Shi,Zhu, Huajie,Chen, Dawei,et al. Pavidolides A-E, new cembranoids from the soft coral Sinularia pavida[J]. TETRAHEDRON LETTERS,2012,53(43):5759-5762.
APA	Shen, Shi.,Zhu, Huajie.,Chen, Dawei.,Liu, Dong.,van Ofwegen, Leen.,...&Lin, Wenhan.(2012).Pavidolides A-E, new cembranoids from the soft coral Sinularia pavida.TETRAHEDRON LETTERS,53(43),5759-5762.
MLA	Shen, Shi,et al."Pavidolides A-E, new cembranoids from the soft coral Sinularia pavida".TETRAHEDRON LETTERS 53.43(2012):5759-5762.