pH-sensitive sodium alginate/poly(vinyl alcohol) hydrogel beads prepared by combined Ca2+ crosslinking and freeze-thawing cycles for controlled release of diclofenac sodium

CORC > 兰州化学物理研究所 > 中国科学院兰州化学物理研究所 > 环境材料与生态化学研究发展中心

	pH-sensitive sodium alginate/poly(vinyl alcohol) hydrogel beads prepared by combined Ca2+ crosslinking and freeze-thawing cycles for controlled release of diclofenac sodium
	Wang AQ(王爱勤)
刊名	International Journal of Biological Macromolecules
	2010
卷号	46 期号:5 页码:517-523
关键词	Alginate Poly(vinyl alcohol) Freezing–thawing Swelling Release
ISSN号	0141-8130
通讯作者	王爱勤 aqwang@licp.cas.cn
中文摘要	In order to enhance the drug entrapment efficiency and improve the swelling behaviors of drug delivery system, Ca2+ crosslinking and freeze-thawing (FT) cycle techniques were used to prepare sodium alginate/poly(vinyl alcohol) (SA/PVA) hydrogel beads. The mixture solution of SA and PVA was firstly crosslinked with Ca2+ to form beads and then subjected to freezing–thawing cycles for further crosslinking. The crosslinking process was confirmed by Fourier transform infrared spectroscopy (FTIR) and X-ray diffraction (XRD). The swelling and pH-sensitive properties of the beads were investigated, and the drug loading and controlled release properties of the beads were also evaluated using diclofenac sodium as the model drug. Results indicate that the bead was formed well and the encapsulation efficiency was greatly improved when the ratio of PVA to SA is 3:1. The swelling and degradation of the developed beads was influenced by pH of the test medium and PVA content. FT process enhanced drug entrapment efficiency, improved swelling behaviors and slowed release of drug from the dual crosslinked beads compared with pure SA beads crosslinked with Ca2+ ion alone, which provide a facile and effective method to improve the drug delivery system.
学科主题	药物释放
收录类别	SCI
资助信息	中科院院长奖获得者科研启动专项(2008-06)
语种	英语
WOS记录号	WOS:000278586200008
公开日期	2012-09-02
内容类型	期刊论文
源URL	[http://210.77.64.217/handle/362003/129]
专题	兰州化学物理研究所_环境材料与生态化学研究发展中心
推荐引用方式 GB/T 7714	Wang AQ. pH-sensitive sodium alginate/poly(vinyl alcohol) hydrogel beads prepared by combined Ca2+ crosslinking and freeze-thawing cycles for controlled release of diclofenac sodium[J]. International Journal of Biological Macromolecules,2010,46(5):517-523.
APA	王爱勤.(2010).pH-sensitive sodium alginate/poly(vinyl alcohol) hydrogel beads prepared by combined Ca2+ crosslinking and freeze-thawing cycles for controlled release of diclofenac sodium.International Journal of Biological Macromolecules,46(5),517-523.
MLA	王爱勤."pH-sensitive sodium alginate/poly(vinyl alcohol) hydrogel beads prepared by combined Ca2+ crosslinking and freeze-thawing cycles for controlled release of diclofenac sodium".International Journal of Biological Macromolecules 46.5(2010):517-523.