Property and application of novel ferrocenyl–azobenzene labeled peptide nucleic acid monomers with the dual stimulus–response characteristics

CORC > 兰州化学物理研究所 > 中国科学院兰州化学物理研究所 > 固体润滑国家重点实验室

	Property and application of novel ferrocenyl–azobenzene labeled peptide nucleic acid monomers with the dual stimulus–response characteristics
	Yang SR(杨生荣); Wang JQ(王金清)
刊名	Inorganica Chimica Acta
	2009
卷号	362 页码:4174-4178
关键词	Peptide nucleic acid Azobenzene Ferrocene Photoisomerization Detection limit
ISSN号	0020-1693
通讯作者	王金清 ; 陈淼
中文摘要	In this work, three novel types of peptide nucleic acid (PNA) monomers labeled by ferrocenyl–azoben- zene units (Fc–Azo–PNAs, 1a, 1b, and 1c) have been synthesized and they all exhibited good reversible photoswitch and redox properties. In the different solvents of ethanol (EtOH) and acetonitrile (ACN), photoisomerization rate constants (K) of three PNA monomers under UV light irradiation have also been analyzed and compared, discovering that the values of K are closely correlative to their molecular struc- tures. The electrochemical properties of the synthesized PNA monomers are also investigated and the typical redox properties are displayed, demonstrating that they can be regarded as the anchor to be grafted at the end of PNA oligomers for detecting themselves. Finally, according to the analyses of UV– Vis absorption spectrum and differential pulse voltammetry (DPV), the synthesized PNA monomers afford the best detection limit down to 10 8 M in EtOH. The results also illuminate that PNA monomers with new photo–redox dual stimulus–response characteristics can be realized to detect themselves by the metal complex unit together with azo moiety; moreover, the hybridization with DNA also can be tuned by the isomerization of azo moiety.
学科主题	材料科学与物理化学
收录类别	SCI
资助信息	the National Natural Science Foundation of China (Grant Nos. 20823008;50801065);“Top Hundred Talents Program” of Chinese Academy of Sciences
语种	英语
公开日期	2012-11-13
内容类型	期刊论文
源URL	[http://210.77.64.217/handle/362003/2043]
专题	兰州化学物理研究所_固体润滑国家重点实验室
通讯作者	Wang JQ(王金清)
推荐引用方式 GB/T 7714	Yang SR,Wang JQ. Property and application of novel ferrocenyl–azobenzene labeled peptide nucleic acid monomers with the dual stimulus–response characteristics[J]. Inorganica Chimica Acta,2009,362:4174-4178.
APA	杨生荣,&王金清.(2009).Property and application of novel ferrocenyl–azobenzene labeled peptide nucleic acid monomers with the dual stimulus–response characteristics.Inorganica Chimica Acta,362,4174-4178.
MLA	杨生荣,et al."Property and application of novel ferrocenyl–azobenzene labeled peptide nucleic acid monomers with the dual stimulus–response characteristics".Inorganica Chimica Acta 362(2009):4174-4178.