| An OR logic gate based on two molecular beacons |
| Guo, Jing; Yang, Renqiang
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| 刊名 | MOLECULAR BIOSYSTEMS
 |
| 2012
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| 卷号 | 8期号:3页码:927-930 |
| 中文摘要 | | Design of elementary molecular logic gates is the key and the fundamental of performing complicated Boolean calculations. Herein, we report a strategy for constructing a DNA-based OR gate by using the mechanism of sequence recognition and the principle of fluorescence resonance energy transfer (FRET). In this system, the gate is entirely composed of a single strand of DNA (A, B and C) and the inputs are the molecular beacon probes (MB1 and MB2). Changes in fluorescence intensity confirm the realization of the OR logic operation and electrophoresis experiments verify these results. Our successful application of DNA to perform the binary operation represents that DNA can serve as an efficient biomaterial for designing molecular logic gates and devices. |
|
| 英文摘要 | Design of elementary molecular logic gates is the key and the fundamental of performing complicated Boolean calculations. Herein, we report a strategy for constructing a DNA-based OR gate by using the mechanism of sequence recognition and the principle of fluorescence resonance energy transfer (FRET). In this system, the gate is entirely composed of a single strand of DNA (A, B and C) and the inputs are the molecular beacon probes (MB1 and MB2). Changes in fluorescence intensity confirm the realization of the OR logic operation and electrophoresis experiments verify these results. Our successful application of DNA to perform the binary operation represents that DNA can serve as an efficient biomaterial for designing molecular logic gates and devices. |
| 学科主题 | 先进功能有机材料
|
| WOS标题词 | Science & Technology
; Life Sciences & Biomedicine
|
| 类目[WOS] | Biochemistry & Molecular Biology
|
| 研究领域[WOS] | Biochemistry & Molecular Biology
|
| 关键词[WOS] | DNA LOGIC
; CHEMICAL INPUTS
; COMPUTATION
; CIRCUITS
; QUADRUPLEX
; PROTEINS
; BINDING
; DESIGN
; ENZYME
; PH
|
| 收录类别 | SCI
|
| 语种 | 英语
|
| WOS记录号 | WOS:000300048500028
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| 公开日期 | 2012-11-10
|
| 内容类型 | 期刊论文
|
| 源URL | [http://ir.qibebt.ac.cn:8080/handle/337004/1191]  |
| 专题 | 青岛生物能源与过程研究所_先进有机功能材料团队
|
| 作者单位 | Chinese Acad Sci, Qingdao Inst Bioenergy & Bioproc Technol, Qingdao 266101, Peoples R China
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推荐引用方式
GB/T 7714 |
Guo, Jing,Yang, Renqiang. An OR logic gate based on two molecular beacons[J]. MOLECULAR BIOSYSTEMS,2012,8(3):927-930.
|
| APA |
Guo, Jing,&Yang, Renqiang.(2012).An OR logic gate based on two molecular beacons.MOLECULAR BIOSYSTEMS,8(3),927-930.
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| MLA |
Guo, Jing,et al."An OR logic gate based on two molecular beacons".MOLECULAR BIOSYSTEMS 8.3(2012):927-930.
|
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