Mechanisms of the interaction between Pr(DNR)(3) and herring-sperm DNA

	Mechanisms of the interaction between Pr(DNR)(3) and herring-sperm DNA
	Liu, Xiaocai ; Wang, Xingming ; Ding, Lisheng
刊名	JOURNAL OF THE SERBIAN CHEMICAL SOCIETY
	2011
卷号	76 期号:10 页码:1365-1378
关键词	daunorubicin rare earth complexes herring-sperm DNA acridine orange interaction mechanism
ISSN号	0352-5139
通讯作者	Wang, XM (reprint author), SW Univ Sci & Technol, Sch Mat Sci & Engn, Mianyang 62101, Peoples R China.
产权排序	2
英文摘要	Research on the interaction mechanism of drugs with DNA is essential to understand their pharmacokinetics. The interaction between rare earth complexes Pr(DNR)(3) and herring-sperm DNA was studied in Tris-HCl buffer solution (pH 7.4) by absorption and fluorescence spectroscopy and viscosity measurements. The results showed that the modes of interaction between Pr(DNR)(3) and herring-sperm DNA were electrostatic and intercalation. The binding ratio was n(Pr(DNA)3): n(DNA) = 5:1 and the binding constant was K-circle minus(292 K) = 4.34x10(3) L mol(-1). Furthermore, according to the double reciprocal method and the thermodynamic equation, the intercalative interaction was cooperatively driven by an enthalpy effect and an entropy effect.
学科主题	Chemistry
收录类别	SCI
资助信息	National Natural Science Foundation of China[30973634]; Postgraduate Innovation Foundation of Southwest University of Science and Technology. Mianyang, China
语种	英语
WOS记录号	WOS:000296821000004
公开日期	2012-11-09
内容类型	期刊论文
源URL	[http://210.75.237.14/handle/351003/23578]
专题	成都生物研究所_天然产物研究
推荐引用方式 GB/T 7714	Liu, Xiaocai,Wang, Xingming,Ding, Lisheng. Mechanisms of the interaction between Pr(DNR)(3) and herring-sperm DNA[J]. JOURNAL OF THE SERBIAN CHEMICAL SOCIETY,2011,76(10):1365-1378.
APA	Liu, Xiaocai,Wang, Xingming,&Ding, Lisheng.(2011).Mechanisms of the interaction between Pr(DNR)(3) and herring-sperm DNA.JOURNAL OF THE SERBIAN CHEMICAL SOCIETY,76(10),1365-1378.
MLA	Liu, Xiaocai,et al."Mechanisms of the interaction between Pr(DNR)(3) and herring-sperm DNA".JOURNAL OF THE SERBIAN CHEMICAL SOCIETY 76.10(2011):1365-1378.