Spectroscopic studies on the interaction of gamma-cyclodextrin daunorubicin inclusion complex with herring sperm DNA

	Spectroscopic studies on the interaction of gamma-cyclodextrin daunorubicin inclusion complex with herring sperm DNA
	Xu, Dongling ; Wang, Xingming ; Ding, Lisheng
刊名	CARBOHYDRATE POLYMERS
	2011
卷号	83 期号:3 页码:1257-1262
关键词	Spectrometry gamma-Cyclodextrin Daunorubicin Inclusion complex Herring sperm DNA
ISSN号	0144-8617
通讯作者	Wang, XM (reprint author), SW Univ Sci & Technol, Mat Sci & Engn Coll, Dept Chem, Mianyang 621010, Sichuan, Peoples R China.
产权排序	2
英文摘要	The interaction of daunorubicin (DNR) with herring sperm DNA in cyclomaltooctaose (gamma-cyclodextrin, abbrev. gamma-CD) supramolecular system was studied by UV-vis absorption spectroscopy, fluorescence spectroscopy and viscosity method. On the condition of physiological pH, the results indicate that DNR prefers to form the 1:1 inclusion complex with gamma-CD. These results are further supported by infrared spectrometry (IR), and X-ray diffraction (XRD). An inclusion constant (K) for the formation of gamma-CD-DNR inclusion complex has been evaluated to be 9412.39 L mol(-1) from the absorbance changes. It is observed that the interaction mode between gamma-CD-DNR and DNA are a mixed binding, which contains partial intercalation and groove binding. The binding ratio of gamma-CD-DNR with DNA is n(gamma-CD-DNR):n(DNA) = 10:1, binding constant is K(295.15K)(circle minus) = 2.44 x 10(5) L mol(-1), enthalpy and entropy work as driven force in this action. Crown Copyright (C) 2010 Published by Elsevier Ltd. All rights reserved.
学科主题	Chemistry; Polymer Science
收录类别	SCI
资助信息	National Natural Science Foundation of China[30572254]
语种	英语
WOS记录号	WOS:000286965300033
公开日期	2012-11-09
内容类型	期刊论文
源URL	[http://210.75.237.14/handle/351003/23564]
专题	成都生物研究所_天然产物研究
推荐引用方式 GB/T 7714	Xu, Dongling,Wang, Xingming,Ding, Lisheng. Spectroscopic studies on the interaction of gamma-cyclodextrin daunorubicin inclusion complex with herring sperm DNA[J]. CARBOHYDRATE POLYMERS,2011,83(3):1257-1262.
APA	Xu, Dongling,Wang, Xingming,&Ding, Lisheng.(2011).Spectroscopic studies on the interaction of gamma-cyclodextrin daunorubicin inclusion complex with herring sperm DNA.CARBOHYDRATE POLYMERS,83(3),1257-1262.
MLA	Xu, Dongling,et al."Spectroscopic studies on the interaction of gamma-cyclodextrin daunorubicin inclusion complex with herring sperm DNA".CARBOHYDRATE POLYMERS 83.3(2011):1257-1262.