Enantioselective Separation of Indole Derivatives by Liquid Chromatography Using Immobilized Cellulose (3,5-Dimethylphenylcarbamate) Chiral Stationary Phase

CORC > 兰州化学物理研究所 > 中国科学院兰州化学物理研究所 > 中科院西北特色植物资源化学重点实验室/甘肃省天然药物重点实验室

	Enantioselective Separation of Indole Derivatives by Liquid Chromatography Using Immobilized Cellulose (3,5-Dimethylphenylcarbamate) Chiral Stationary Phase
	Jiang SX(蒋生祥); Zhao L(赵亮); Zhao L(赵亮)
刊名	Journal of Analytical Chemistry
	2009
卷号	64 期号:8 页码:795-805
ISSN号	1061－9348
通讯作者	赵亮
中文摘要	A new chiral stationary phase of 3,5-dimethylphenylcarbamates of cellulose chemically bonded to 3-aminopropyl silica gel was prepared, which may be used with a wide range of solvents including standard and non-standard ones. Several racemic indole derivatives have been resolved using standard and non-standard solvents on the immobilized chiral column (15 cm×0.46 cm) at a flow rate of 1.0 mL/min or 0.5 mL/min with a UV detection at 230 nm. Separation of indole derivatives on immobilized and coated chiral stationary phases(CSP) in HPLC using a mixture of hexane/2-propanol as mobile phase was compared. The resolution factors for immobilized and coated chiral column were 0.57–2.02 and 0.61–4.03, respectively. It was found that both coated and immbolized chiral stationary phases were suitable for the separation of indole derivatives; however, the coated CSP possesses a higher resolving power than the immobilized one.
学科主题	分析化学与药物化学
收录类别	SCI
资助信息	National Natural Science Foundation of China (No. 20375045,20675085);the Natural Science Foundation of Gansu province (No-3ZS041-A25-23);the Light in Chinese Western Region (2003)
语种	英语
WOS记录号	WOS:000268492300005
公开日期	2012-09-29
内容类型	期刊论文
源URL	[http://210.77.64.217/handle/362003/1191]
专题	兰州化学物理研究所_中科院西北特色植物资源化学重点实验室/甘肃省天然药物重点实验室
通讯作者	Zhao L(赵亮); Zhao L(赵亮)
推荐引用方式 GB/T 7714	Jiang SX,Zhao L,Zhao L. Enantioselective Separation of Indole Derivatives by Liquid Chromatography Using Immobilized Cellulose (3,5-Dimethylphenylcarbamate) Chiral Stationary Phase[J]. Journal of Analytical Chemistry,2009,64(8):795-805.
APA	蒋生祥,赵亮,&赵亮.(2009).Enantioselective Separation of Indole Derivatives by Liquid Chromatography Using Immobilized Cellulose (3,5-Dimethylphenylcarbamate) Chiral Stationary Phase.Journal of Analytical Chemistry,64(8),795-805.
MLA	蒋生祥,et al."Enantioselective Separation of Indole Derivatives by Liquid Chromatography Using Immobilized Cellulose (3,5-Dimethylphenylcarbamate) Chiral Stationary Phase".Journal of Analytical Chemistry 64.8(2009):795-805.