Toxicity of the brominated flame retardant tris-(2,3-dibromopropyl) isocyanurate in zebrafish (Danio rerio)

CORC > 生态环境研究中心 > 中国科学院生态环境研究中心 > 环境化学与生态毒理学国家重点实验室

	Toxicity of the brominated flame retardant tris-(2,3-dibromopropyl) isocyanurate in zebrafish (Danio rerio)
	Zhang Xu ; Li Juan ; Chen MinJie ; Wu Le ; Zhang Chi ; Zhang Jie ; Zhou QunFang ; Liang Yong
刊名	CHINESE SCIENCE BULLETIN
	2011-05-01
卷号	56 期号:15 页码:1548—1555
中文摘要	Tris-(2,3-dibromopropyl) isocyanurate (TBC) is a heterocyclic brominated flame retardant that was recently detected in the environment in China. TBC is semi-volatile and can accumulate in the lipid of some species, but little is known about its effect on aquatic organisms. We exposed adult zebrafish to 0, 0.25, 1 and 4 mg/L TBC for 28 d and measured the effect on survival, growth, histopathology, hormone levels, enzyme activity, and gene expression. TBC exposure had no effect on survival or growth. We observed significant damage to the liver and gill, including hepatocellular swelling and fatty degeneration in the liver as well as proliferation and edema of epithelial cells in the gills. In addition, exposure to 4 mg/L TBC induced proliferation of goblet cells in the intestine of both sexes, acellular areas in the testis, and thinly scattered vitellogenic granules in vitellogenic oocytes. TBC exposure had no effect on the levels of thyroid hormones, testosterone, estradiol, liver superoxide dismutase activity, malondialdehyde content, and brain cholinesterase activity. By contrast, hepatic vitellogenin and cytochrome P4501A gene expression was significantly down-regulated in both male and female zebrafish in response to TBC exposure. Our results suggest that exposure to TBC causes a variety of potential reproductive and endocrine toxic effects.
WOS记录号	WOS:000290274900006
公开日期	2012-10-18
内容类型	期刊论文
源URL	[http://ir.rcees.ac.cn/handle/311016/7078]
专题	生态环境研究中心_环境化学与生态毒理学国家重点实验室
推荐引用方式 GB/T 7714	Zhang Xu,Li Juan,Chen MinJie,et al. Toxicity of the brominated flame retardant tris-(2,3-dibromopropyl) isocyanurate in zebrafish (Danio rerio)[J]. CHINESE SCIENCE BULLETIN,2011,56(15):1548—1555.
APA	Zhang Xu.,Li Juan.,Chen MinJie.,Wu Le.,Zhang Chi.,...&Liang Yong.(2011).Toxicity of the brominated flame retardant tris-(2,3-dibromopropyl) isocyanurate in zebrafish (Danio rerio).CHINESE SCIENCE BULLETIN,56(15),1548—1555.
MLA	Zhang Xu,et al."Toxicity of the brominated flame retardant tris-(2,3-dibromopropyl) isocyanurate in zebrafish (Danio rerio)".CHINESE SCIENCE BULLETIN 56.15(2011):1548—1555.