The mouse SLIT family: Secreted ligands for ROBO expressed in patterns that suggest a role in morphogenesis and axon guidance

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	The mouse SLIT family: Secreted ligands for ROBO expressed in patterns that suggest a role in morphogenesis and axon guidance
	Yuan, WL ; Zhou, LJ ; Chen, TH ; Wu, JY ; Rao, Y ; Ornitz, DM
刊名	DEVELOPMENTAL BIOLOGY
	1999
卷号	212 期号:2 页码:290-306
关键词	NEURAL CREST MIGRATION NERVOUS-SYSTEM CNS MIDLINE MOLECULAR-CLONING LIMB DEVELOPMENT SPINAL-CORD MOTOR AXONS CHICK DROSOPHILA PROTEINS
ISSN号	0012-1606
通讯作者	Ornitz, DM (reprint author), Washington Univ, Sch Med, Dept Mol Biol & Pharmacol, 660 S Euclid Ave, St Louis, MO 63110 USA,
英文摘要	The Slit gene encodes a secreted molecule essential for neural development in Drosophila embryos. Here we report the identification of three Slit homologues in the mouse. We demonstrate that the mouse SLIT1 protein can bind ROBO1, a transmembrane receptor implicated in axon guidance. Both whole-mount and section in situ hybridization studies reveal unique and complementary patterns of expression of the three mouse Slit genes and of Robo1, both within the central nervous system and in other developing tissues. The complementary expression patterns of Slit and Robo1 and their in vitro interaction suggest a ligand-receptor relationship. The expression of all three Slit genes in the floor plate suggests that they are likely to share the same functional properties with their Drosophila homologue in midline neural development and axon guidance. The complementary expression of Slit and Robo1 in different subdivisions of the somites suggests their possible function in axon pathfinding and neural crest cell migration. The unique expression pattern in Limb and other organs indicates additional potential functions of the Slit gene family. (C) 1999 Academic Press.
学科主题	Developmental Biology
收录类别	SCI
语种	英语
公开日期	2012-07-23
内容类型	期刊论文
源URL	[http://ir.sibs.ac.cn/handle/331001/2099]
专题	上海神经科学研究所_神经所(总)
推荐引用方式 GB/T 7714	Yuan, WL,Zhou, LJ,Chen, TH,et al. The mouse SLIT family: Secreted ligands for ROBO expressed in patterns that suggest a role in morphogenesis and axon guidance[J]. DEVELOPMENTAL BIOLOGY,1999,212(2):290-306.
APA	Yuan, WL,Zhou, LJ,Chen, TH,Wu, JY,Rao, Y,&Ornitz, DM.(1999).The mouse SLIT family: Secreted ligands for ROBO expressed in patterns that suggest a role in morphogenesis and axon guidance.DEVELOPMENTAL BIOLOGY,212(2),290-306.
MLA	Yuan, WL,et al."The mouse SLIT family: Secreted ligands for ROBO expressed in patterns that suggest a role in morphogenesis and axon guidance".DEVELOPMENTAL BIOLOGY 212.2(1999):290-306.