Regulation of neuregulin signaling by PSD-95 interacting with ErbB4 at CNS synapses

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	Regulation of neuregulin signaling by PSD-95 interacting with ErbB4 at CNS synapses
	Huang, YZ ; Won, S ; Ali, DW ; Wang, Q ; Tanowitz, M ; Du, QS ; Pelkey, KA ; Yang, DJ ; Xiong, WC ; Salter, MW ; Mei, L
刊名	NEURON
	2000
卷号	26 期号:2 页码:443-455
关键词	RECEPTOR GENE-EXPRESSION NEU DIFFERENTIATION FACTOR TUMOR-SUPPRESSOR GENE DENSITY PROTEIN PSD-95 LONG-TERM POTENTIATION POSTSYNAPTIC DENSITY GROWTH-FACTOR TYROSINE KINASES NERVOUS-SYSTEM RAT-BRAIN
ISSN号	0896-6273
通讯作者	Mei, L (reprint author), Univ Alabama, Dept Neurobiol Pathol & Phys Med & Rehabil, Birmingham, AL 35294 USA,
英文摘要	Neuregulins (NRGs) and their receptors, the ErbB protein tyrosine kinases, are essential for neuronal development, but their functions in the adult CNS are unknown. We report that ErbB4 is enriched in the postsynaptic density (PSD) and associates with PSD-95. Heterologous expression of PSD-95 enhanced NRG activation of ErbB4 and MAP kinase. Conversely, inhibiting expression of PSD-95 in neurons attenuated NRG-mediated activation of MAP kinase. PSD-95 formed a ternary complex with two molecules of ErbB4, suggesting that PSD-95 facilitates ErbB4 dimerization. Finally, NRG suppressed induction of long-term potentiation in the hippocampal CA1 region without affecting basal synaptic transmission. Thus, NRG signaling may be synaptic and regulated by PSD-95. A role of NRG signaling in the adult CNS may be modulation of synaptic plasticity.
学科主题	Neurosciences & Neurology
收录类别	SCI
语种	英语
公开日期	2012-07-23
内容类型	期刊论文
源URL	[http://ir.sibs.ac.cn/handle/331001/2091]
专题	上海神经科学研究所_神经所(总)
推荐引用方式 GB/T 7714	Huang, YZ,Won, S,Ali, DW,et al. Regulation of neuregulin signaling by PSD-95 interacting with ErbB4 at CNS synapses[J]. NEURON,2000,26(2):443-455.
APA	Huang, YZ.,Won, S.,Ali, DW.,Wang, Q.,Tanowitz, M.,...&Mei, L.(2000).Regulation of neuregulin signaling by PSD-95 interacting with ErbB4 at CNS synapses.NEURON,26(2),443-455.
MLA	Huang, YZ,et al."Regulation of neuregulin signaling by PSD-95 interacting with ErbB4 at CNS synapses".NEURON 26.2(2000):443-455.