Altered expression of tissue-type plasminogen activator and type 1 inhibitor in astrocytes of mouse cortex following scratch injury in culture

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	Altered expression of tissue-type plasminogen activator and type 1 inhibitor in astrocytes of mouse cortex following scratch injury in culture
	Tang, HB ; Fu, WY ; Ip, NY
刊名	NEUROSCIENCE LETTERS
	2000
卷号	285 期号:2 页码:143-146
关键词	astrocytes regeneration tissue-type plasminogen activator urokinase-type plasminogen activator type 1 plasminogen activator inhibitor 6-amino-caproitic acid DEVELOPING CEREBELLUM MESSENGER-RNA UROKINASE DEGRADATION SYSTEM CELLS
ISSN号	0304-3940
通讯作者	Ip, NY (reprint author), Chinese Acad Sci, Shanghai Res Ctr Life Sci, Shanghai, Peoples R China,
英文摘要	The expression of plasminogen and plasminogen activators (PG/PAs) in reactive astrocytes was examined following scratch injury. In response to injury, casein-degrading activity could be observed around astrocytes. The protein expression of tissue-type plasminogen activator (tPA) was up-regulated, while the free form of urokinase-type plasminogen activator (uPA) was not detected. Consistent with these findings, results obtained with zymograph assay also revealed that tPA activity, but not uPA activity, was up-regulated. Moreover, the addition of 6-amino-caproitic acid (EACA) to casein-covered astrocytes significantly prevented the recovery of the injured astrocytes in a dose-dependent manner. Taken together, our data demonstrate that the expression of PG/PAs in cultured astrocytes is regulated following injury, suggesting that caseinolytic activity is an essential component during the process of astrocyte recovery. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.
学科主题	Neurosciences & Neurology
收录类别	SCI
语种	英语
公开日期	2012-07-23
内容类型	期刊论文
源URL	[http://ir.sibs.ac.cn/handle/331001/2088]
专题	上海神经科学研究所_神经所(总)
推荐引用方式 GB/T 7714	Tang, HB,Fu, WY,Ip, NY. Altered expression of tissue-type plasminogen activator and type 1 inhibitor in astrocytes of mouse cortex following scratch injury in culture[J]. NEUROSCIENCE LETTERS,2000,285(2):143-146.
APA	Tang, HB,Fu, WY,&Ip, NY.(2000).Altered expression of tissue-type plasminogen activator and type 1 inhibitor in astrocytes of mouse cortex following scratch injury in culture.NEUROSCIENCE LETTERS,285(2),143-146.
MLA	Tang, HB,et al."Altered expression of tissue-type plasminogen activator and type 1 inhibitor in astrocytes of mouse cortex following scratch injury in culture".NEUROSCIENCE LETTERS 285.2(2000):143-146.