Induction of tumor angiogenesis by Slit-Robo signaling and inhibition of cancer growth by blocking Robo activity | |
Wang, B ; Xiao, Y ; Ding, BB ; Zhang, N ; Yuan, XB ; Gui, L ; Qian, KX ; Duan, SM ; Chen, ZJ ; Rao, Y ; Geng, JG | |
刊名 | CANCER CELL |
2003 | |
卷号 | 4期号:1页码:19-29 |
关键词 | REPULSIVE AXON GUIDANCE NEURONAL MIGRATION HEPARAN-SULFATE LEUKOCYTE CHEMOTAXIS VERTEBRATE SLIT P-SELECTIN PROTEIN DROSOPHILA ADHESION RECEPTORS |
ISSN号 | 1535-6108 |
通讯作者 | Geng, JG (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Mol Cell Biol Lab, Inst Biochem & Cell Biol, Beijing 200031, Peoples R China, |
英文摘要 | Slit is a secreted protein known to function through the Roundabout (Robo) receptor as a chemorepellent in axon guidance and neuronal migration, and as an inhibitor in leukocyte chemotaxis. Here we show Slit2 expression in a large number of solid tumors and Robo1 expression in vascular endothelial cells. Recombinant Slit2 protein attracted endothelial cells and promoted tube formation in a Robo1- and phosphatidylinositol kinase-dependent manner. Neutralization of Robo1 reduced the microvessel density and the tumor mass of human malignant melanoma A375 cells in vivo. These findings demonstrate the angiogenic function of Slit-Robo signaling, reveal a mechanism in mediating the crosstalk between cancer cells and endothelial cells, and indicate the effectiveness of blocking this signaling pathway in treating cancers. |
学科主题 | Oncology ; Cell Biology |
收录类别 | SCI |
语种 | 英语 |
公开日期 | 2012-07-23 |
内容类型 | 期刊论文 |
源URL | [http://ir.sibs.ac.cn/handle/331001/2015] |
专题 | 上海神经科学研究所_神经所(总) |
推荐引用方式 GB/T 7714 | Wang, B,Xiao, Y,Ding, BB,et al. Induction of tumor angiogenesis by Slit-Robo signaling and inhibition of cancer growth by blocking Robo activity[J]. CANCER CELL,2003,4(1):19-29. |
APA | Wang, B.,Xiao, Y.,Ding, BB.,Zhang, N.,Yuan, XB.,...&Geng, JG.(2003).Induction of tumor angiogenesis by Slit-Robo signaling and inhibition of cancer growth by blocking Robo activity.CANCER CELL,4(1),19-29. |
MLA | Wang, B,et al."Induction of tumor angiogenesis by Slit-Robo signaling and inhibition of cancer growth by blocking Robo activity".CANCER CELL 4.1(2003):19-29. |
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