Neuregulin induces proliferation of neural progenitor cells via PLC/PKC pathway

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	Neuregulin induces proliferation of neural progenitor cells via PLC/PKC pathway
	Lai, C ; Feng, LY
刊名	BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
	2004
卷号	319 期号:2 页码:603-611
关键词	neural progenitor cell neuregulin proliferation PLC PKQ TPA ACTIVATED PROTEIN-KINASE FIBROBLAST-GROWTH-FACTOR STEM-CELLS NEUROTROPHIC FACTOR PHOSPHOLIPASE-C CORTICAL-NEURONS EPITHELIAL-CELLS PRECURSOR CELLS CANCER CELLS MAP KINASE
ISSN号	0006-291X
通讯作者	Feng, LY (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China,lyfeiig@sibs.ac.cn
英文摘要	Nestin-expressing neural progenitor cells (NPCs) have been isolated from hippocampus of brains and propagated with epidermal growth factor and basic fibroblast growth factor (bFGF). However, the underlying signaling mechanisms regulating NPC proliferation remain elusive. Here we showed that neuregulinbeta1 (NRG), like bFGF, effectively promoted the proliferation of hippocampus-derived NPCs and maintained the progenitor states of NPCs. Activation of protein kinase C (PKC), a downstream effector of phospholipase C (PLC), with 12-O-tetradecanoylphorbol-13-acetate (TPA) mimicked the NRG-induced proliferation of NPCs. The synergic effect of TPA plus NRG on neurosphere growth further prompted us to find that NRG induced NPC propagation through PLC/PKC signaling pathway. ErbB4, an important functional receptor of NRG, had an interaction with PLCgamma1 protein. In addition, inactivation of PLC pathway led to severe proliferative suppression of NPCs. Our study suggests that activation of PLC/PKC pathway plays an essential role in the NRG-induced proliferation of hippocampus-derived NPCs. (C) 2004 Elsevier Inc. All rights reserved.
学科主题	Biochemistry & Molecular Biology ; Biophysics
收录类别	SCI
语种	英语
公开日期	2012-07-23
内容类型	期刊论文
源URL	[http://ir.sibs.ac.cn/handle/331001/1955]
专题	上海神经科学研究所_神经所(总)
推荐引用方式 GB/T 7714	Lai, C,Feng, LY. Neuregulin induces proliferation of neural progenitor cells via PLC/PKC pathway[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2004,319(2):603-611.
APA	Lai, C,&Feng, LY.(2004).Neuregulin induces proliferation of neural progenitor cells via PLC/PKC pathway.BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,319(2),603-611.
MLA	Lai, C,et al."Neuregulin induces proliferation of neural progenitor cells via PLC/PKC pathway".BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 319.2(2004):603-611.