Target-specific differences in somatodendritic morphology of layer V pyramidal neurons in rat motor cortex

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	Target-specific differences in somatodendritic morphology of layer V pyramidal neurons in rat motor cortex
	Gao, WJ ; Zheng, ZH
刊名	JOURNAL OF COMPARATIVE NEUROLOGY
	2004
卷号	476 期号:2 页码:174-185
关键词	dendrites retrograde tracing corticospinal corticostriatal corticothalamic intracellular injection CAT VISUAL-CORTEX PRIMARY SOMATOSENSORY CORTEX DENDRITIC MORPHOLOGY CORTICOTHALAMIC PROJECTIONS INTRACELLULAR HRP CEREBRAL-CORTEX CORTICOSTRIATAL NEURONS TERMINAL DISTRIBUTION SPINE DISTRIBUTIONS NEOCORTICAL NEURONS
ISSN号	0021-9967
通讯作者	Gao, WJ (reprint author), Yale Univ, Sch Med, Dept Neurobiol, SHM B403,333 Cedar St, New Haven, CT 06510 USA,wen-jun.gao@yale.edu
英文摘要	Dendritic geometry has been shown to be a critical determinant of information processing and neuronal computation. However, it is not known whether cortical projection neurons that target different subcortical nuclei have distinct dendritic morphologies. In this study, fast blue retrograde tracing in combination with intracellular Lucifer yellow injection and diaminobenzidine (DAB) photoconversion in fixed slices was used to study the morphological features of corticospinal, corticostriatal, and corticothalamic neurons in layer V of rat motor cortex. Marked differences in the distribution of soma, somal size, and dendritic profiles were found among the three groups of pyramidal neurons. Corticospinal neurons were large, were located in deep layer V, and had the most expansive dendritic fields. The apical dendrites of corticospinal pyramidal neurons were thick, spiny, and branched. In contrast, nearly all corticostriatal neurons were small cells located in superficial layer V. Their apical dendritic shafts were significantly more slender, though spiny like those of corticospinal neurons. Corticothalamic neurons, which were located in superficial layer V and in layer VI, had small or medium-sized soma, slender apical dendritic shafts, and dendrites that were largely spine free. This study indicates that, in layer V of rat motor cortex, each population of projection neurons has a unique somatodendritic morphology and suggests that distinct modes of cortical information processing are operative in corticospinal, corticostriatal, and corticothalamic neurons. (C) 2004 Wiley-Liss, Inc.
学科主题	Neurosciences & Neurology ; Zoology
收录类别	SCI
语种	英语
公开日期	2012-07-23
内容类型	期刊论文
源URL	[http://ir.sibs.ac.cn/handle/331001/1949]
专题	上海神经科学研究所_神经所(总)
推荐引用方式 GB/T 7714	Gao, WJ,Zheng, ZH. Target-specific differences in somatodendritic morphology of layer V pyramidal neurons in rat motor cortex[J]. JOURNAL OF COMPARATIVE NEUROLOGY,2004,476(2):174-185.
APA	Gao, WJ,&Zheng, ZH.(2004).Target-specific differences in somatodendritic morphology of layer V pyramidal neurons in rat motor cortex.JOURNAL OF COMPARATIVE NEUROLOGY,476(2),174-185.
MLA	Gao, WJ,et al."Target-specific differences in somatodendritic morphology of layer V pyramidal neurons in rat motor cortex".JOURNAL OF COMPARATIVE NEUROLOGY 476.2(2004):174-185.