Development of the mouse retina: Emerging morphological diversity of the ganglion cells | |
Diao, L ; Sun, WZ ; Deng, QD ; He, SG | |
刊名 | JOURNAL OF NEUROBIOLOGY
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2004 | |
卷号 | 61期号:2页码:236-249 |
关键词 | dendritic field branching pattern stratification DiI gene gun MEDIATED AFFERENT ACTIVITY RABBIT RETINA CAT RETINA DENDRITIC STRATIFICATION ALPHA-GANGLION INNER RETINA MATURATION RAT MICE BETA |
ISSN号 | 0022-3034 |
通讯作者 | He, SG (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Neurosci, 320 Yue Yang Rd, Shanghai 200031, Peoples R China,s.he@ion.ac.cn |
英文摘要 | The time course and regulatory mechanisms of dendritic development are subjects of intense interest. We approached these problems by investigating dendritic morphology of retinal ganglion cells (RGCs) at four early postnatal stages. The RGCs develop from a diffusely stratified and poorly differentiated group at birth (P0), to 16 distinct, morphologically well-defined subtypes before eye opening (P13). Even before bipolar cells make synaptic contacts with the RGCs (P8), most adultlike RGC subtypes are already present. Similar to previous studies in other mammalian species, our results indicate that the initiation of the RGC morphological maturation is independent of light stimulation and of formation of glutamatergic synapses. This study narrowed down the window of RGCs morphological maturation and highlighted a few early postnatal events as potential factors controlling the developmental process. Because mouse is the most popular mammalian model for genetic manipulation, this study provided a foundation for further exploring regulatory mechanisms of RGC dendritic development. (C) 2004 Wiley Periodicals, Inc. |
学科主题 | Neurosciences & Neurology |
收录类别 | SCI |
语种 | 英语 |
公开日期 | 2012-07-23 |
内容类型 | 期刊论文 |
源URL | [http://ir.sibs.ac.cn/handle/331001/1939] ![]() |
专题 | 上海神经科学研究所_神经所(总) |
推荐引用方式 GB/T 7714 | Diao, L,Sun, WZ,Deng, QD,et al. Development of the mouse retina: Emerging morphological diversity of the ganglion cells[J]. JOURNAL OF NEUROBIOLOGY,2004,61(2):236-249. |
APA | Diao, L,Sun, WZ,Deng, QD,&He, SG.(2004).Development of the mouse retina: Emerging morphological diversity of the ganglion cells.JOURNAL OF NEUROBIOLOGY,61(2),236-249. |
MLA | Diao, L,et al."Development of the mouse retina: Emerging morphological diversity of the ganglion cells".JOURNAL OF NEUROBIOLOGY 61.2(2004):236-249. |
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