Both the establishment and the maintenance of neuronal polarity require active mechanisms: Critical roles of GSK-3 beta and its upstream regulators

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	Both the establishment and the maintenance of neuronal polarity require active mechanisms: Critical roles of GSK-3 beta and its upstream regulators
	Jiang, H ; Guo, W ; Liang, XH ; Rao, Y
刊名	CELL
	2005
卷号	120 期号:1 页码:123-135
关键词	GLYCOGEN-SYNTHASE KINASE-3 CULTURED HIPPOCAMPAL-NEURONS DISPERSED CELL-CULTURE PROTEIN-KINASE GROWTH CONES TUMOR-SUPPRESSOR AXON FORMATION PHOSPHORYLATION INHIBITION TAU
ISSN号	0092-8674
通讯作者	Rao, Y (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Neurosci, Grad Sch, 320 Yueyang Rd, Shanghai 200031, Peoples R China,y-rao@northwestem.edu
英文摘要	Axon-dendrite polarity is a cardinal feature of neuronal morphology essential for information flow. Here we report a differential distribution of GSK-3beta activity in the axon versus the dendrites. A constitutively active GSK-3beta mutant inhibited axon formation, whereas multiple axons formed from a single neuron when GSK-3beta activity was reduced by pharmacological inhibitors, a peptide inhibitor, or siRNAs. An active mechanism for maintaining neuronal polarity was revealed by the conversion of preexisting dendrites into axons upon GSK-3 inhibition. Biochemical and functional data show that the Akt kinase and the PTEN phosphatase are upstream of GSK-3beta in determining neuronal polarity. Our results demonstrate that there are active mechanisms for maintaining as well as establishing neuronal polarity, indicate that GSK-3beta relays signaling from Akt and PTEN to play critical roles in neuronal polarity, and suggest that application of GSK-3beta inhibitors can be a novel approach to promote generation of new axons after neural injuries.
学科主题	Biochemistry & Molecular Biology ; Cell Biology
收录类别	SCI
语种	英语
公开日期	2012-07-23
内容类型	期刊论文
源URL	[http://ir.sibs.ac.cn/handle/331001/1924]
专题	上海神经科学研究所_神经所(总)
推荐引用方式 GB/T 7714	Jiang, H,Guo, W,Liang, XH,et al. Both the establishment and the maintenance of neuronal polarity require active mechanisms: Critical roles of GSK-3 beta and its upstream regulators[J]. CELL,2005,120(1):123-135.
APA	Jiang, H,Guo, W,Liang, XH,&Rao, Y.(2005).Both the establishment and the maintenance of neuronal polarity require active mechanisms: Critical roles of GSK-3 beta and its upstream regulators.CELL,120(1),123-135.
MLA	Jiang, H,et al."Both the establishment and the maintenance of neuronal polarity require active mechanisms: Critical roles of GSK-3 beta and its upstream regulators".CELL 120.1(2005):123-135.