Inhibitors of GlyT1 and GlyT2 differentially modulate inhibitory transmission

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	Inhibitors of GlyT1 and GlyT2 differentially modulate inhibitory transmission
	Xu, TX ; Gong, N ; Xu, TL(徐天乐)
刊名	NEUROREPORT
	2005
卷号	16 期号:11 页码:1227-1231
关键词	cotransmission gamma-aminobutyric acid type A receptors glycine receptors glycine transporter 1 glycine transporter 2 miniature inhibitory postsynaptic currents spinal dorsal horn neuron DORSAL COMMISSURAL NEURONS RAT SPINAL-CORD SYNAPTIC-TRANSMISSION GLYCINE TRANSPORTERS GABA MOTONEURONS RECEPTORS CORELEASE CNS
ISSN号	0959-4965
通讯作者	Xu, TL (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Neurosci, Shanghai 200031, Peoples R China,tlxu@ion.ac.cn
英文摘要	The chronic effects of glycine transporter I and 2 inhibitors (sarcosine and ALX-1393, respectively) on miniature inhibitory postsynaptic currents were studied in cultured spinal neurons. We found that sarcosine increased the frequency of overall miniature inhibitory postsynaptic currents without affecting the ratio of glycinergic, mixed and GABAergic miniature inhibitory postsynaptic currents, whereas ALX-1393 changed the ratio by increasing the proportions of GABAergic and mixed miniature inhibitory post-synaptic currents without affecting overall mIPSC frequency. We propose that inhibition of glycine transporter I by sarcosine increased overall mIPSC frequency via the activation of presynaptic glycine receptors, while inhibition of glycine transporter 2 by ALX-1393 changed the ratio of glycinergic, mixed and GABAergic miniature inhibitory postsynaptic currents by shifting the balance of inhibitory transmitters in vesicles towards gamma-aminobutyric acid.
学科主题	Neurosciences & Neurology
收录类别	SCI
语种	英语
公开日期	2012-07-23
内容类型	期刊论文
源URL	[http://ir.sibs.ac.cn/handle/331001/1891]
专题	上海神经科学研究所_神经所(总)
推荐引用方式 GB/T 7714	Xu, TX,Gong, N,Xu, TL. Inhibitors of GlyT1 and GlyT2 differentially modulate inhibitory transmission[J]. NEUROREPORT,2005,16(11):1227-1231.
APA	Xu, TX,Gong, N,&Xu, TL.(2005).Inhibitors of GlyT1 and GlyT2 differentially modulate inhibitory transmission.NEUROREPORT,16(11),1227-1231.
MLA	Xu, TX,et al."Inhibitors of GlyT1 and GlyT2 differentially modulate inhibitory transmission".NEUROREPORT 16.11(2005):1227-1231.