Novel stimulus-induced calcium efflux in Drosophila mushroom bodies

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	Novel stimulus-induced calcium efflux in Drosophila mushroom bodies
	Peng, Yueqing ; Guo, Aike
刊名	EUROPEAN JOURNAL OF NEUROSCIENCE
	2007
卷号	25 期号:7 页码:2034-2044
关键词	calcium imaging calcium signals electrical stimulation GABA receptor sodium-calcium exchanger GREEN FLUORESCENT PROTEIN NA+/CA2+ EXCHANGER OLFACTORY NEURONS SENSORY NEURONS RUTHENIUM RED BODY NEURONS MECHANISMS INHIBITION HONEYBEE CELLS
ISSN号	0953-816X
通讯作者	Guo, AK (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Neurosci, Key Lab Neurobiol, 320 Yueyang Rd, Shanghai 200031, Peoples R China,akguo@ion.ac.cn
英文摘要	The mushroom body (MB) is an important part of the Drosophila brain, and is involved in many behaviors, including olfactory learning and memory and some visual cognition. However, the physiological properties of MB neurons remain elusive. Here we used a calcium-imaging technique to study calcium signals in Drosophila MB. We found that, rather than increasing calcium spread, electrical stimuli dramatically decreased calcium signals in the terminals of MB fibers. This novel calcium decrease occurred at all developmental stages from larvae to adults, but was specific for certain regions of the MB neurons. GABA receptor blockade promoted calcium propagation through the MB fibers, but did not disrupt the stimulus-induced decrease in calcium. Furthermore, this decrease in calcium was independent of extracellular calcium concentration and was not due to altered uptake by intracellular calcium stores and mitochondria. Rather, we found that inhibition of sodium-calcium exchangers significantly attenuated the stimulus-induced decrease in calcium, whereas the decrease persisted when membrane calcium pumps were blocked. Our findings indicate that MB neurons exhibit a novel stimulus-induced calcium efflux, which may be importantly regulated by sodium-calcium exchangers in the Drosophila MB.
学科主题	Neurosciences & Neurology
收录类别	SCI
语种	英语
公开日期	2012-07-23
内容类型	期刊论文
源URL	[http://ir.sibs.ac.cn/handle/331001/1780]
专题	上海神经科学研究所_神经所(总)
推荐引用方式 GB/T 7714	Peng, Yueqing,Guo, Aike. Novel stimulus-induced calcium efflux in Drosophila mushroom bodies[J]. EUROPEAN JOURNAL OF NEUROSCIENCE,2007,25(7):2034-2044.
APA	Peng, Yueqing,&Guo, Aike.(2007).Novel stimulus-induced calcium efflux in Drosophila mushroom bodies.EUROPEAN JOURNAL OF NEUROSCIENCE,25(7),2034-2044.
MLA	Peng, Yueqing,et al."Novel stimulus-induced calcium efflux in Drosophila mushroom bodies".EUROPEAN JOURNAL OF NEUROSCIENCE 25.7(2007):2034-2044.