Role of IGF signaling in olfactory sensory map formation and axon guidance

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	Role of IGF signaling in olfactory sensory map formation and axon guidance
	Scolnick, Jonathan A. ; Cui, Kai ; Duggan, Cynthia D. ; Xuan, Shouhong ; Yuan, Xiao-Bing ; Efstratiadis, Argiris ; Ngai, John
刊名	NEURON
	2008
卷号	57 期号:6 页码:847-857
关键词	GROWTH CONE GUIDANCE RECEPTOR GENE-EXPRESSION FACTOR-II GENE ODORANT RECEPTOR TOPOGRAPHIC MAP MICE DEFICIENT MOTOR-NEURONS BULB SYSTEM GLOMERULI
ISSN号	0896-6273
通讯作者	Ngai, J (reprint author), Univ Calif Berkeley, Helen Wills Neurosci Inst, Funct Genom Lab, Dept Mol & Cell Biol, Berkeley, CA 94720 USA,jngai@socrates.berkeley.edu
英文摘要	Olfactory neurons project their axons to spatially invariant glomeruli in the olfactory bulb, forming an ordered pattern of innervation comprising the olfactory sensory map. A mirror symmetry exists within this map, such that neurons expressing a given receptor typically project to one glomerulus on the medial face and one glomerulus on the lateral face of the bulb. The mechanisms underlying an olfactory neuron's choice to project medially versus laterally remain largely unknown, however. Here we demonstrate that insulin-like growth factor (IGF) signaling is required for sensory innervation of the lateral olfactory bulb. Mutations that eliminate IGF signaling cause axons destined for targets in the lateral bulb to shift to ectopic sites on the ventral-medial surface. Using primary cultures of olfactory and cerebellar neurons, we further show that IGF is a chemoattractant for axon growth cones. Together these observations reveal a role of IGF signaling in sensory map formation and axon guidance.
学科主题	Neurosciences & Neurology
收录类别	SCI
语种	英语
公开日期	2012-07-23
内容类型	期刊论文
源URL	[http://ir.sibs.ac.cn/handle/331001/1735]
专题	上海神经科学研究所_神经所(总)
推荐引用方式 GB/T 7714	Scolnick, Jonathan A.,Cui, Kai,Duggan, Cynthia D.,et al. Role of IGF signaling in olfactory sensory map formation and axon guidance[J]. NEURON,2008,57(6):847-857.
APA	Scolnick, Jonathan A..,Cui, Kai.,Duggan, Cynthia D..,Xuan, Shouhong.,Yuan, Xiao-Bing.,...&Ngai, John.(2008).Role of IGF signaling in olfactory sensory map formation and axon guidance.NEURON,57(6),847-857.
MLA	Scolnick, Jonathan A.,et al."Role of IGF signaling in olfactory sensory map formation and axon guidance".NEURON 57.6(2008):847-857.