Cortical action potential backpropagation explains spike threshold variability and rapid-onset kinetics

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	Cortical action potential backpropagation explains spike threshold variability and rapid-onset kinetics
	Shu, Yousheng
刊名	JOURNAL OF NEUROSCIENCE
	2008
卷号	28 期号:29 页码:7260-7272
关键词	axon kink Hodgkin-Huxley pyramidal cell spike timing Na+ channels NEURONS IN-VIVO AXON INITIAL SEGMENT NEOCORTICAL PYRAMIDAL NEURONS SYNAPTIC CONDUCTANCES COINCIDENCE DETECTION CELLS CHANNELS MODEL DENDRITES CORTEX
ISSN号	0270-6474
通讯作者	McCormick, DA (reprint author), Yale Univ, Sch Med, Kavli Inst Neurosci, Dept Neurobiol, 333 Cedar St, New Haven, CT 06510 USA,david.mccormick@yale.edu
英文摘要	Neocortical action potential responses in vivo are characterized by considerable threshold variability, and thus timing and rate variability, even under seemingly identical conditions. This finding suggests that cortical ensembles are required for accurate sensorimotor integration and processing. Intracellularly, trial-to-trial variability results not only from variation in synaptic activities, but also in the transformation of these into patterns of action potentials. Through simultaneous axonal and somatic recordings and computational simulations, we demonstrate that the initiation of action potentials in the axon initial segment followed by backpropagation of these spikes throughout the neuron results in a distortion of the relationship between the timing of synaptic and action potential events. In addition, this backpropagation also results in an unusually high rate of rise of membrane potential at the foot of the action potential. The distortion of the relationship between the amplitude time course of synaptic inputs and action potential output caused by spike backpropagation results in the appearance of high spike threshold variability at the level of the soma. At the point of spike initiation, the axon initial segment, threshold variability is considerably less. Our results indicate that spike generation in cortical neurons is largely as expected by Hodgkin-Huxley theory and is more precise than previously thought.
学科主题	Neurosciences & Neurology
收录类别	SCI
语种	英语
公开日期	2012-07-23
内容类型	期刊论文
源URL	[http://ir.sibs.ac.cn/handle/331001/1712]
专题	上海神经科学研究所_神经所(总) 上海神经科学研究所_神经网络功能研究组
推荐引用方式 GB/T 7714	Shu, Yousheng. Cortical action potential backpropagation explains spike threshold variability and rapid-onset kinetics[J]. JOURNAL OF NEUROSCIENCE,2008,28(29):7260-7272.
APA	Shu, Yousheng.(2008).Cortical action potential backpropagation explains spike threshold variability and rapid-onset kinetics.JOURNAL OF NEUROSCIENCE,28(29),7260-7272.
MLA	Shu, Yousheng."Cortical action potential backpropagation explains spike threshold variability and rapid-onset kinetics".JOURNAL OF NEUROSCIENCE 28.29(2008):7260-7272.