Choice strategies in Drosophila are based on competition between olfactory memories

CORC > 上海神经科学研究所 > 中国科学院上海生命科学研究院神经科学研究所 > 神经所(总)

	Choice strategies in Drosophila are based on competition between olfactory memories
	Yin, Yan ; Chen, Nannan ; Zhang, Shixing ; Guo, Aike
刊名	EUROPEAN JOURNAL OF NEUROSCIENCE
	2009
卷号	30 期号:2 页码:279-288
关键词	coexisting memories decision linear subtraction olfactory conditioning previous experiences DECISION-MAKING MUSHROOM BODY CONSOLIDATED MEMORY GENERAL MECHANISM MELANOGASTER NEURONS RETENTION DOPAMINE BEHAVIOR PHASES
ISSN号	0953-816X
通讯作者	Guo, AK (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, State Key Lab Neurosci, Inst Neurosci, 320 Yueyang Rd, Shanghai 200031, Peoples R China,akguo@ion.ac.cn
英文摘要	The brain mechanisms by which animals deal with multiple experiences to predict outcomes are not yet fully understood. We explored the choice strategies that flies use to assess degrees of disadvantage, as well as how flies weigh past and recent experiences to guide decisions. Drosophila were exposed to two conditioning events in a T-maze: an odor paired with an electric shock followed by a second odor paired with an electric shock of a different intensity. Subsequently, flies were forced to choose between the two odors. We found that flies chose to avoid the more 'dangerous' odor by a linear subtraction mechanism that was based on two coexisting memories. We also found that flies weighed experiences of the same danger level (60 V electric shocks) according to the times when the experiences had occurred. More recent experiences had a greater impact and past experiences gradually became 'overlooked' during decisions as the time delay between the two events lengthened. However, the past memory was not so much disrupted as it was overshadowed by recent memories during decisions. Finally, when a past experience was more disadvantageous, wild-type flies were able to coordinate both the temporal factor and the degree of disadvantage into their decisions. By contrast, amnesiac mutant flies made choices completely according to the temporal factor, ignoring the degree of disadvantage. Taken together, wild-type flies are able to store multiple olfactory memories and can coherently evaluate learned experiences to guide their decisions according to the degree of disadvantage and/or the temporal factor.
学科主题	Neurosciences & Neurology
收录类别	SCI
资助信息	National Science Foundation of China[30270341, 30630028, 30621004, 30770511]; Chinese Academy of Sciences[G2000077800, 2006CB806600, r2006CB911003, KJCX1-09-03, KSCX2-YW-R-28]
语种	英语
公开日期	2012-07-13
内容类型	期刊论文
源URL	[http://ir.sibs.ac.cn/handle/331001/1655]
专题	上海神经科学研究所_神经所(总)
推荐引用方式 GB/T 7714	Yin, Yan,Chen, Nannan,Zhang, Shixing,et al. Choice strategies in Drosophila are based on competition between olfactory memories[J]. EUROPEAN JOURNAL OF NEUROSCIENCE,2009,30(2):279-288.
APA	Yin, Yan,Chen, Nannan,Zhang, Shixing,&Guo, Aike.(2009).Choice strategies in Drosophila are based on competition between olfactory memories.EUROPEAN JOURNAL OF NEUROSCIENCE,30(2),279-288.
MLA	Yin, Yan,et al."Choice strategies in Drosophila are based on competition between olfactory memories".EUROPEAN JOURNAL OF NEUROSCIENCE 30.2(2009):279-288.