Drosophila TRPA Channel Painless Inhibits Male-Male Courtship Behavior through Modulating Olfactory Sensation

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	Drosophila TRPA Channel Painless Inhibits Male-Male Courtship Behavior through Modulating Olfactory Sensation
	Wang, Zuoren
刊名	PLOS ONE
	2011
卷号	6 期号:11 页码:e25890-e25891
关键词	SEXUAL RECEPTIVITY SOCIAL EXPERIENCE MELANOGASTER PHEROMONE GENE NOCICEPTION AVOIDANCE TASTE FLY
ISSN号	1932-6203
通讯作者	Wang, KY (reprint author), Chinese Acad Sci, Inst Neurosci, Shanghai Inst Biol Sci, State Key Lab Neurosci, Shanghai, Peoples R China,ZuorenWang@ion.ac.cn
英文摘要	The Drosophila melanogaster TRPA family member painless, expressed in a subset of multidendritic neurons embeding in the larval epidermis, is necessary for larval nociception of noxious heat or mechanical stimuli. However, the function of painless in adult flies remains largely unknown. Here we report that mutation of painless leads to a defect in male-male courtship behavior and alteration in olfaction sensitivity in adult flies. Specific downregulation of the expression of the Painless protein in the olfactory projection neurons (PNs) of the antennal lobes (ALs) resulted in a phenotype resembling that found in painless mutant flies, whereas overexpression of Painless in PNs of painless mutant males suppressed male-male courtship behavior. The downregulation of Painless exclusively during adulthood also resulted in male-male courtship behavior. In addition, mutation of the painless gene in flies caused changes in olfaction, suggesting a role for this gene in olfactory processing. These results indicate that functions of painless in the adult central nervous system of Drosophila include modulation of olfactory processing and inhibition of male-male courtship behavior.
学科主题	Life Sciences & Biomedicine - Other Topics
收录类别	SCI
资助信息	China 973 project[2011CBA00404]
语种	英语
公开日期	2012-07-13
内容类型	期刊论文
源URL	[http://ir.sibs.ac.cn/handle/331001/1526]
专题	上海神经科学研究所_神经所(总) 上海神经科学研究所_神经环路与动物行为研究组
推荐引用方式 GB/T 7714	Wang, Zuoren. Drosophila TRPA Channel Painless Inhibits Male-Male Courtship Behavior through Modulating Olfactory Sensation[J]. PLOS ONE,2011,6(11):e25890-e25891.
APA	Wang, Zuoren.(2011).Drosophila TRPA Channel Painless Inhibits Male-Male Courtship Behavior through Modulating Olfactory Sensation.PLOS ONE,6(11),e25890-e25891.
MLA	Wang, Zuoren."Drosophila TRPA Channel Painless Inhibits Male-Male Courtship Behavior through Modulating Olfactory Sensation".PLOS ONE 6.11(2011):e25890-e25891.