Functional study of hyperpolarization activated channel (I-h) in Drosophila behavior

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	Functional study of hyperpolarization activated channel (I-h) in Drosophila behavior
	Wang ZuoRen
刊名	SCIENCE CHINA-LIFE SCIENCES
	2012
卷号	55 期号:1 页码:40946
关键词	I-h channel Drosophila melanogaster HCN behavior ION CHANNELS PACEMAKER MELANOGASTER NEURONS INTEGRATION
ISSN号	1674-7305
通讯作者	Wang, ZR (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Neurosci, State Key Lab Neurosci, Shanghai 200031, Peoples R China,zuorenwang@ion.ac.cn
英文摘要	Hyperpolarization-activated, cyclic nucleotide-gated and cation-nonselective ion channels (I (h) channels, or HCN channels) are known to play important roles in mammals. Their physiological functions in invertebrate remain largely unclear. Here, we report our studies with I (h) channel in Drosophila melanogaster. Drosophila Ih channel mutants are found with several defects by behavioral analyses. Their lifespan is reduced, and their chemical sensitivity is shifted. In addition, their length of sleep at light-dark condition is mildly reduced. We generated transgenic flies of I (h) promoter-driven Gal4 and examined its expression pattern in both larvae and adult flies. Our results suggest that I (h) channel may play diverse roles in Drosophila and provide a basis to further expand our understanding of Drosophila Ih channel function in vivo.
学科主题	Life Sciences & Biomedicine - Other Topics
收录类别	SCI
语种	英语
公开日期	2012-07-13
内容类型	期刊论文
源URL	[http://ir.sibs.ac.cn/handle/331001/1511]
专题	上海神经科学研究所_神经所(总)
推荐引用方式 GB/T 7714	Wang ZuoRen. Functional study of hyperpolarization activated channel (I-h) in Drosophila behavior[J]. SCIENCE CHINA-LIFE SCIENCES,2012,55(1):40946.
APA	Wang ZuoRen.(2012).Functional study of hyperpolarization activated channel (I-h) in Drosophila behavior.SCIENCE CHINA-LIFE SCIENCES,55(1),40946.
MLA	Wang ZuoRen."Functional study of hyperpolarization activated channel (I-h) in Drosophila behavior".SCIENCE CHINA-LIFE SCIENCES 55.1(2012):40946.