Bidirectional modification of presynaptic neuronal excitability accompanying spike timing-dependent synaptic plasticity

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	Bidirectional modification of presynaptic neuronal excitability accompanying spike timing-dependent synaptic plasticity
	Poo, MM; Li, CY
刊名	NEURON
	2004
卷号	41 期号:2 页码:257-268
关键词	LONG-TERM POTENTIATION PROTEIN-KINASE-C HIPPOCAMPAL PYRAMIDAL CELLS SPINY STELLATE NEURONS INTRINSIC EXCITABILITY BARREL CORTEX POTASSIUM CURRENTS NEURAL-NETWORKS K+ CHANNELS ACTIVATION
ISSN号	0896-6273
通讯作者	Duan, SM (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Neurosci, Shanghai 200031, Peoples R China,shumin@ion.ac.cn ; rnpoo@uclink.berkeley.edu
英文摘要	Correlated pre- and postsynaptic activity that induces long-term potentiation is known to induce a persistent enhancement of the intrinsic excitability of the presynaptic neuron. Here we report that, associated with the induction of long-term depression in hippocampal cultures and in somatosensory cortical slices, there is also a persistent reduction in the excitability of the presynaptic neuron. This reduction requires postsynaptic Ca2+ elevation and presynaptic PKA- and PKC-dependent modification of slow-inactivating K+ channels. The bidirectional changes in neuronal excitability and synaptic efficacy exhibit identical requirements for the temporal order of pre- and postsynaptic activation but reflect two distinct aspects of activity-induced modification of neural circuits.
学科主题	Neurosciences & Neurology
收录类别	SCI
语种	英语
公开日期	2012-07-23
内容类型	期刊论文
源URL	[http://ir.sibs.ac.cn/handle/331001/1982]
专题	上海神经科学研究所_神经所(总) 上海神经科学研究所_神经可塑性研究组
推荐引用方式 GB/T 7714	Poo, MM,Li, CY. Bidirectional modification of presynaptic neuronal excitability accompanying spike timing-dependent synaptic plasticity[J]. NEURON,2004,41(2):257-268.
APA	Poo, MM,&Li, CY.(2004).Bidirectional modification of presynaptic neuronal excitability accompanying spike timing-dependent synaptic plasticity.NEURON,41(2),257-268.
MLA	Poo, MM,et al."Bidirectional modification of presynaptic neuronal excitability accompanying spike timing-dependent synaptic plasticity".NEURON 41.2(2004):257-268.