Long-range Ca2+ signaling from growth cone to soma mediates reversal of neuronal migration induced by Slit-2

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	Long-range Ca2+ signaling from growth cone to soma mediates reversal of neuronal migration induced by Slit-2
	Poo, Mu-ming
刊名	CELL
	2007
卷号	129 期号:2 页码:385-395
关键词	RHO-FAMILY GTPASES LEECH RETZIUS NEURONS NERVE GROWTH AXON GUIDANCE ENDOPLASMIC-RETICULUM DIRECTIONAL GUIDANCE REGULATED FORMATION TARGET CONTACT IN-VIVO CALCIUM
ISSN号	0092-8674
通讯作者	Poo, MM (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Neurosci, Shanghai 200031, Peoples R China,yuanxb@ion.ac.cn ; mpoo@berkeley.edu
英文摘要	Neuronal migration and growth-cone extension are both guided by extracellular factors in the developing brain, but whether these two forms of guidance are mechanistically linked is unclear. Application of a Slit-2 gradient in front of the leading process of cultured cerebellar granule cells led to the collapse of the growth cone and the reversal of neuronal migration, an event preceded by a propagating Ca2+ wave from the growth cone to the soma. The Ca2+ wave was required for the Slit-2 effect and was sufficient by itself to induce the reversal of migration. The Slit-2-induced reversal of migration required active RhoA, which was accumulated at the front of the migrating neuron, and this polarized RhoA distribution was reversed during the migration reversal induced by either the Slit-2 gradient or the Ca (2+) wave. Thus, longrange Ca (2+) signaling coordinates the Slit-2induced changes in motility at two distant parts of migrating neurons by regulating RhoA distribution.
学科主题	Biochemistry & Molecular Biology ; Cell Biology
收录类别	SCI
语种	英语
公开日期	2012-07-23
内容类型	期刊论文
源URL	[http://ir.sibs.ac.cn/handle/331001/1777]
专题	上海神经科学研究所_神经所(总) 上海神经科学研究所_神经可塑性研究组
推荐引用方式 GB/T 7714	Poo, Mu-ming. Long-range Ca2+ signaling from growth cone to soma mediates reversal of neuronal migration induced by Slit-2[J]. CELL,2007,129(2):385-395.
APA	Poo, Mu-ming.(2007).Long-range Ca2+ signaling from growth cone to soma mediates reversal of neuronal migration induced by Slit-2.CELL,129(2),385-395.
MLA	Poo, Mu-ming."Long-range Ca2+ signaling from growth cone to soma mediates reversal of neuronal migration induced by Slit-2".CELL 129.2(2007):385-395.