TRPC channels promote cerebellar granule neuron survival

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	TRPC channels promote cerebellar granule neuron survival
	Wang, Yizheng
刊名	NATURE NEUROSCIENCE
	2007
卷号	10 期号:5 页码:559-567
关键词	NERVE GROWTH CONES SIGNALING PATHWAY CELL-DEATH CREB PHOSPHORYLATION TRANSCRIPTION FACTOR NEUROTROPHIC FACTOR CALCIUM-CHANNEL GENE-EXPRESSION CATION CHANNELS KINASE PATHWAY
ISSN号	1097-6256
通讯作者	Wang, YZ (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Neurosci, Key Lab Neurobiol,Lab Neural Signal Transduct, 320 Yue Yang Rd, Shanghai 200031, Peoples R China,yzwang@ion.ac.cn
英文摘要	Channels formed by the transient receptor potential (TRP) family of proteins have a variety of physiological functions. Here we report that two members of the TRP cation channel (TRPC) subfamily, TRPC3 and 6, protected cerebellar granule neurons ( CGNs) against serum deprivation - induced cell death in cultures and promoted CGN survival in rat brain. In CGN cultures, blocking TRPC channels or downregulating TRPC3 or 6 suppressed brain- derived neurotrophic factor ( BDNF) - mediated protection, BDNF-triggered intracellular Ca2+ elevation and BDNF-induced CREB activation. By contrast, overexpressing TRPC3 or 6 increased CREB-dependent reporter gene transcription and prevented apoptosis in the neurons deprived of serum, and this protection was blocked by the dominant negative form of CREB. Furthermore, downregulating TRPC3 or 6 induced CGN apoptosis in neonatal rat cerebellum, and this effect was rescued by overexpressing either TRPC3 or 6. Thus, our findings provide in vitro and in vivo evidence that TRPC channels are important in promoting neuronal survival.
学科主题	Neurosciences & Neurology
收录类别	SCI
语种	英语
公开日期	2012-07-23
内容类型	期刊论文
源URL	[http://ir.sibs.ac.cn/handle/331001/1775]
专题	上海神经科学研究所_神经所(总) 上海神经科学研究所_神经信号转导研究组
推荐引用方式 GB/T 7714	Wang, Yizheng. TRPC channels promote cerebellar granule neuron survival[J]. NATURE NEUROSCIENCE,2007,10(5):559-567.
APA	Wang, Yizheng.(2007).TRPC channels promote cerebellar granule neuron survival.NATURE NEUROSCIENCE,10(5),559-567.
MLA	Wang, Yizheng."TRPC channels promote cerebellar granule neuron survival".NATURE NEUROSCIENCE 10.5(2007):559-567.