Critical role of TRPC6 channels in the formation of excitatory synapses

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	Critical role of TRPC6 channels in the formation of excitatory synapses
	Wang, Yizheng; Yao, Hailan
刊名	NATURE NEUROSCIENCE
	2008
卷号	11 期号:7 页码:741-743
关键词	DENDRITIC SPINES MEMORY ACTIVATION BDNF
ISSN号	1097-6256
通讯作者	Wang, YZ (reprint author), Shanghai Inst Biol Sci, Inst Neurosci, State Key Lab Neurosci, Lab Neural Signal Transduct, Shanghai 200031, Peoples R China,yzwang@ion.ac.cn
英文摘要	The transient receptor potential canonical (TRPC) channels are Ca(2+)-permeable, nonselective cation channels with different biological functions, but their roles in brain are largely unknown. Here we report that TRPC6 was localized to excitatory synapses and promoted their formation via a CaMKIV-CREB-dependent pathway. TRPC6 transgenic mice showed enhancement in spine formation, and spatial learning and memory in Morris water maze. These results reveal a previously unknown role of TRPC6 in synaptic and behavioral plasticity.
学科主题	Neurosciences & Neurology
收录类别	SCI
语种	英语
公开日期	2012-07-23
内容类型	期刊论文
源URL	[http://ir.sibs.ac.cn/handle/331001/1722]
专题	上海神经科学研究所_神经所(总) 上海神经科学研究所_神经信号转导研究组
推荐引用方式 GB/T 7714	Wang, Yizheng,Yao, Hailan. Critical role of TRPC6 channels in the formation of excitatory synapses[J]. NATURE NEUROSCIENCE,2008,11(7):741-743.
APA	Wang, Yizheng,&Yao, Hailan.(2008).Critical role of TRPC6 channels in the formation of excitatory synapses.NATURE NEUROSCIENCE,11(7),741-743.
MLA	Wang, Yizheng,et al."Critical role of TRPC6 channels in the formation of excitatory synapses".NATURE NEUROSCIENCE 11.7(2008):741-743.