Circadian modulation of light-induced locomotion responses in Drosophila melanogaster

CORC > 上海神经科学研究所 > 中国科学院上海生命科学研究院神经科学研究所 > 神经所(总)

	Circadian modulation of light-induced locomotion responses in Drosophila melanogaster
	Guo, A.
刊名	GENES BRAIN AND BEHAVIOR
	2008
卷号	7 期号:7 页码:730-739
关键词	arrhythmic mutants circadian rhythm Drosophila light locomotion responses normal masking paradoxical masking PIGMENT-DISPERSING FACTOR LATERAL NEURONS CLOCK PROTEIN FRUIT-FLIES RHYTHMS GENE PERIOD CRYPTOCHROME MASKING OSCILLATOR
ISSN号	1601-1848
通讯作者	Guo, A (reprint author), Chinese Acad Sci, Inst Biophys, State Key Lab Brain & Cognit Sci, Beijing 100101, Peoples R China,akguo@ion.ac.cn
英文摘要	The relationship between light and the circadian system has long been a matter of discussion. Many studies have focused on entrainment of light with the internal biological clock. Light also functions as an environmental stimulus that affects the physiology and behaviour of animals directly. In this study, we used light as an unexpected stimulus for flies at different circadian times. We found that wildtype flies showed circadian changes in light-induced locomotion responses. Elevation of locomotor activity by light occurred during the subjective night, and performance in response to light pulses declined to trough during the subjective day. Moreover, arrhythmic mutants lost the rhythm of locomotion responses to light, with promotion of activity by light in timeless(01) mutants and inhibition of activity by light in Clock(ar) mutants. However, neither ablation of central oscillators nor disturbance of the functional clock inside compound eyes was sufficient to disrupt the rhythm of light responses. We show that, compound eyes, which have been identified as the control point for normal masking (promotion of activity by light), are sufficient but not necessary for paradoxical masking (suppression of activity by light) under high light intensity. This, taken together with the clear difference of light responses in wildtype flies, suggests that two different masking mechanisms may underlie the circadian modulation of light-induced locomotion responses.
学科主题	Behavioral Sciences ; Neurosciences & Neurology
收录类别	SCI
资助信息	National Science Foundation of China[30270341, 30630028, 30621004, 30770511]; Chinese Academy of Sciences, the Major State Basic Research Program[G2000077800, 2006CB806600, 2006CB911003]; Chinese Academy of Sciences[KJCX1-09-03, KSCX2-YW-R-28]
语种	英语
公开日期	2012-07-23
内容类型	期刊论文
源URL	[http://ir.sibs.ac.cn/handle/331001/1698]
专题	上海神经科学研究所_神经所(总) 上海神经科学研究所_学习与记忆研究组
推荐引用方式 GB/T 7714	Guo, A.. Circadian modulation of light-induced locomotion responses in Drosophila melanogaster[J]. GENES BRAIN AND BEHAVIOR,2008,7(7):730-739.
APA	Guo, A..(2008).Circadian modulation of light-induced locomotion responses in Drosophila melanogaster.GENES BRAIN AND BEHAVIOR,7(7),730-739.
MLA	Guo, A.."Circadian modulation of light-induced locomotion responses in Drosophila melanogaster".GENES BRAIN AND BEHAVIOR 7.7(2008):730-739.