Interaction of Human Serum Album and C-60 Aggregates in Solution

CORC > 生态环境研究中心 > 中国科学院生态环境研究中心 > 环境化学与生态毒理学国家重点实验室

	Interaction of Human Serum Album and C-60 Aggregates in Solution
	Song, Maoyong ; Liu, Shufang ; Yin, Junfa ; Wang, Hailin
刊名	INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
	2011-08-01
卷号	12 期号:8 页码:4964—4974
中文摘要	An important property of C-60 in aquatic ecotoxicology is that it can form stable aggregates with nanoscale dimensions, namely nC(60). Aggregation allows fullerenes to remain suspended for a long time, and the reactivity of individual C-60 is substantially altered in this aggregate form. Herein, we investigated the interaction of nC(60) and human serum album (HSA) using the methods of fluorescence, fluorescence dynamics, circular dichroism (CD), and site marker competitive experiments. We proposed a binding model consistent with the available experimental results for the interactions of nC(60) with HSA. During the interaction process, the structure and conformation of HSA were affected, leading to functional changes of drug binding sites of HSA.
WOS记录号	WOS:000294250800016
公开日期	2012-10-16
内容类型	期刊论文
源URL	[http://ir.rcees.ac.cn/handle/311016/7021]
专题	生态环境研究中心_环境化学与生态毒理学国家重点实验室
推荐引用方式 GB/T 7714	Song, Maoyong,Liu, Shufang,Yin, Junfa,et al. Interaction of Human Serum Album and C-60 Aggregates in Solution[J]. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,2011,12(8):4964—4974.
APA	Song, Maoyong,Liu, Shufang,Yin, Junfa,&Wang, Hailin.(2011).Interaction of Human Serum Album and C-60 Aggregates in Solution.INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,12(8),4964—4974.
MLA	Song, Maoyong,et al."Interaction of Human Serum Album and C-60 Aggregates in Solution".INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 12.8(2011):4964—4974.