Development of an ultra-high-performance liquid chromatography-tandem mass spectrometry method for high throughput determination of organophosphorus flame retardants in environmental water

CORC > 生态环境研究中心 > 中国科学院生态环境研究中心 > 环境化学与生态毒理学国家重点实验室

	Development of an ultra-high-performance liquid chromatography-tandem mass spectrometry method for high throughput determination of organophosphorus flame retardants in environmental water
	Wang, Xiao-wei ; Liu, Jing-fu ; Yin, Yong-guang
刊名	JOURNAL OF CHROMATOGRAPHY A
	2011-09-23
卷号	1218 期号:38 页码:6705—6711
中文摘要	Widely used as flame retardants, organophosphate esters (OPEs) are now broadly present in the indoor and outdoor environments. Currently available liquid chromatography-tandem mass spectrometry (LC-MS/MS) methods share some drawbacks with gas chromatography (GC) methods, including time consuming, limited target OPEs, incomplete separation capability for some OPEs and low throughput. In this study, a fast and high throughput LC-MS/MS method was developed. For the first time, all the twelve OPEs that have been studied in literature, ranging from the very polar and volatile trimethyl phosphate to the very hydrophobic and non-volatile tris(2-ethylhexyl) phosphate, were separated within 11 min. Different from previous studies, we found that the blank contamination was mainly from organic mobile phase rather than the enrichment process, and it can be efficiently eliminated by using acetonitrile rather than methanol as the organic phase of the mobile phase. The signal to noise ratio (S/N) was significantly improved by using 0.1% formic acid as an organic modifier. The method exhibited high throughput and sensitivity and can baseline separate 11 of the 12 OPEs studied within 11 min with LOQs ranging from 2 to 6 ng/L. The relative standard deviations were in the range of 2-10%. For both reagent water and river water, the spiked recoveries of OPEs ranged from 70 to 110%, except for the very polar and volatile trimethyl phosphate that has recovery below 10%. The developed procedure was successfully applied to study the OPE contamination of the Songhua River, and it was found that all the target OPEs were detected with total concentrations of around 1 mu g/L in the river waters. (C) 2011 Elsevier B.V. All rights reserved.
WOS记录号	WOS:000295432700016
公开日期	2012-10-15
内容类型	期刊论文
源URL	[http://ir.rcees.ac.cn/handle/311016/7006]
专题	生态环境研究中心_环境化学与生态毒理学国家重点实验室
推荐引用方式 GB/T 7714	Wang, Xiao-wei,Liu, Jing-fu,Yin, Yong-guang. Development of an ultra-high-performance liquid chromatography-tandem mass spectrometry method for high throughput determination of organophosphorus flame retardants in environmental water[J]. JOURNAL OF CHROMATOGRAPHY A,2011,1218(38):6705—6711.
APA	Wang, Xiao-wei,Liu, Jing-fu,&Yin, Yong-guang.(2011).Development of an ultra-high-performance liquid chromatography-tandem mass spectrometry method for high throughput determination of organophosphorus flame retardants in environmental water.JOURNAL OF CHROMATOGRAPHY A,1218(38),6705—6711.
MLA	Wang, Xiao-wei,et al."Development of an ultra-high-performance liquid chromatography-tandem mass spectrometry method for high throughput determination of organophosphorus flame retardants in environmental water".JOURNAL OF CHROMATOGRAPHY A 1218.38(2011):6705—6711.