In vitro anti-inflammatory activity of 4-arylcoumarins from endophytic Streptomyces aureofaciens CMUAc130 in murine macrophage RAW 264.7 cells

CORC > 昆明植物研究所 > 中国科学院昆明植物研究所 > 植物化学与西部植物资源持续利用国家重点实验室

	In vitro anti-inflammatory activity of 4-arylcoumarins from endophytic Streptomyces aureofaciens CMUAc130 in murine macrophage RAW 264.7 cells
	Taechowisan, Thongchai ; Lu, Chunhua ; Shen, Yuemao ; Lumyong, Saisamorn
刊名	NATURAL PRODUCT RESEARCH
	2007
卷号	21 期号:12 页码:1104-1113
关键词	4-arylcoumarins anti-inflammatory activity endophytic streptomyces murine macrophage RAW 264.7 cells HUMAN-LEUKOCYTE ELASTASE COUMARIN DERIVATIVES ANTIFUNGAL ACTIVITY INHIBITORS LIPOPOLYSACCHARIDE CYCLOOXYGENASE-2 INFLAMMATION ENZYME ACID
ISSN号	1478-6419
通讯作者	Taechowisan, T (reprint author), Silpakorn Univ, Fac Sci, Dept Microbiol, Nakhon Pathom 73000, Thailand. tthongch@su.ac.th
英文摘要	This research was undertaken to find the in vitro inflammatory action of 5,7-dimethoxy4- p-methoxylphenylcoumarin and 5,7-dimethoxy-4-phenylcoumarin produced by Streptomyces aureofaciens CMUAc130. We investigated the effects of 5,7-dimethoxy-4-p-methoxylphenylcoumarin and 5,7-dimethoxy-4-phenylcoumarin not only on the formation of nitric oxide (NO), PGE(2), TNF-alpha, IL-6 and IL-1 beta, but also on inducible NO synthase and cyclooxygenase-2 (COX-2) in lipopolysaccharide (LPS)-induced murine macrophage RAW 264.7 cells. The data obtained were consistent with the modulation of iNOS enzyme expression. A similar fashion was also observed when LPS-induced PGE2 release and COX-2 expression were tested. The significant inhibitory effects were shown in concentration-dependent manners. In addition, 5,7-dimethoxy-4-p-methoxylphenylcoumarin and 5,7-dimethoxy-4-phenylcoumarin also mildly but significantly reduced the formation of TNF-alpha. These findings support the application of 5,7-dimethoxy-4-p-methoxylphenylcoumarin and 5,7-dimethoxy-4-phenylcoumarin as anti-inflammatory agents.
学科主题	Chemistry, Applied; Chemistry, Medicinal
收录类别	SCI
语种	英语
公开日期	2012-10-12
内容类型	期刊论文
源URL	[http://ir.kib.ac.cn/handle/151853/15416]
专题	昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室
推荐引用方式 GB/T 7714	Taechowisan, Thongchai,Lu, Chunhua,Shen, Yuemao,et al. In vitro anti-inflammatory activity of 4-arylcoumarins from endophytic Streptomyces aureofaciens CMUAc130 in murine macrophage RAW 264.7 cells[J]. NATURAL PRODUCT RESEARCH,2007,21(12):1104-1113.
APA	Taechowisan, Thongchai,Lu, Chunhua,Shen, Yuemao,&Lumyong, Saisamorn.(2007).In vitro anti-inflammatory activity of 4-arylcoumarins from endophytic Streptomyces aureofaciens CMUAc130 in murine macrophage RAW 264.7 cells.NATURAL PRODUCT RESEARCH,21(12),1104-1113.
MLA	Taechowisan, Thongchai,et al."In vitro anti-inflammatory activity of 4-arylcoumarins from endophytic Streptomyces aureofaciens CMUAc130 in murine macrophage RAW 264.7 cells".NATURAL PRODUCT RESEARCH 21.12(2007):1104-1113.