Direct Asymmetric Michael Addition of Thioether-based Aryl Sulfanyl-propan-2-one to Nitroalkenes Catalyzed by a Chiral Amine-Thiourea Bifunctional Organocatalyst

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	Direct Asymmetric Michael Addition of Thioether-based Aryl Sulfanyl-propan-2-one to Nitroalkenes Catalyzed by a Chiral Amine-Thiourea Bifunctional Organocatalyst
	Jiang XX(蒋先兴) ; Zhang BZ(张邦治) ; Zhang YF(张义福) ; Lin L(林利) ; Yan WJ(阎文锦) ; Wang R(王锐)
刊名	Chirality
	2010
卷号	22 页码:625-634
关键词	asymmetric Michael addition aryl sulfanyl-propan-2-one nitroalkenes thiourea bifunctional organocatalyst
ISSN号	1520-636X
通讯作者	王锐
中文摘要	Although the organocatalytic direct asymmetric Michael reactions of carbonyl compounds to nitroalkenes have been investigated intensely, the Michael reaction of the thioether-based donors remains a rather undeveloped field. This work concerns the asymmetric Michael addition of aryl sulfanyl-propan-2-one to nitroalkenes with benzoic acid as an additive, and chiral amine-thiourea as a bifunctional organocatalyst. The reactions provided the highly functionalized chiral adducts with excellent enantioselectivities (up to 96% ee) and good yields. Moreover, the further transformed products exhibited excellent diastereoselectivity.
学科主题	物理化学
收录类别	SCI
资助信息	Natural Science Foundation of China (Contract grant numbers: 20525206;20772052;20621091);Chang Jiang Program of the Ministry of Education of China
语种	英语
WOS记录号	WOS:000278832500001
公开日期	2012-09-21
内容类型	期刊论文
源URL	[http://210.77.64.217/handle/362003/486]
专题	兰州化学物理研究所_OSSO国家重点实验室
推荐引用方式 GB/T 7714	Jiang XX,Zhang BZ,Zhang YF,et al. Direct Asymmetric Michael Addition of Thioether-based Aryl Sulfanyl-propan-2-one to Nitroalkenes Catalyzed by a Chiral Amine-Thiourea Bifunctional Organocatalyst[J]. Chirality,2010,22:625-634.
APA	蒋先兴,张邦治,张义福,林利,阎文锦,&王锐.(2010).Direct Asymmetric Michael Addition of Thioether-based Aryl Sulfanyl-propan-2-one to Nitroalkenes Catalyzed by a Chiral Amine-Thiourea Bifunctional Organocatalyst.Chirality,22,625-634.
MLA	蒋先兴,et al."Direct Asymmetric Michael Addition of Thioether-based Aryl Sulfanyl-propan-2-one to Nitroalkenes Catalyzed by a Chiral Amine-Thiourea Bifunctional Organocatalyst".Chirality 22(2010):625-634.