Preparation and characterization of a novel  pH sensitive chitosan-g-poly (acrylic acid)/attapulgite/sodium alginate composite hydrogel bead for controlled release of diclofenac sodium

CORC > 兰州化学物理研究所 > 中国科学院兰州化学物理研究所 > 环境材料与生态化学研究发展中心

	Preparation and characterization of a novel pH sensitive chitosan-g-poly (acrylic acid)/attapulgite/sodium alginate composite hydrogel bead for controlled release of diclofenac sodium
	Zhang JP(张俊平); Wang Q(汪琴); Wang AQ(王爱勤)
刊名	Carbohydrate Polymers
	2009
卷号	78 期号:4 页码:731-737
关键词	Composite hydrogel bead pH-sensitive Controlled release Diclofenac sodium
ISSN号	0144-8617
通讯作者	王爱勤 aqwang@licp.cas.cn
中文摘要	A series of pH-sensitive composite hydrogel beads composed of chitosan-g-poly (acrylic acid)/attapulgite/sodium alginate (CTS-g-PAA/APT/SA) was prepared as drug delivery matrices crosslinked by Ca2+ owing to the ionic gelation of SA. The structure and surface morphology of the composite hydrogel beads were characterized by FTIR and SEM, respectively. pH-sensitivity of these composite hydrogels beads and the release behaviors of drug from them were investigated. The results showed that the composite hydrogel beads had good pH-sensitivity. The cumulative release ratios of diclofenac sodium (DS) from the composite hydrogel beads were 3.76% in pH 2.1 solution and 100% in pH 6.8 solutions within 24 h, respectively. However, the cumulative release ratio of DS in pH 7.4 solution reached 100% within 2 h. The DS cumulative release ratio reduced with increasing APT content from 0 to 50 wt%. The drug release was swelling-controlled at pH 6.8.
学科主题	药物释放
收录类别	SCI
资助信息	中科院西部行动项目(KGCX2-YW-501)
语种	英语
公开日期	2012-09-02
内容类型	期刊论文
源URL	[http://210.77.64.217/handle/362003/161]
专题	兰州化学物理研究所_环境材料与生态化学研究发展中心
推荐引用方式 GB/T 7714	Zhang JP,Wang Q,Wang AQ. Preparation and characterization of a novel pH sensitive chitosan-g-poly (acrylic acid)/attapulgite/sodium alginate composite hydrogel bead for controlled release of diclofenac sodium[J]. Carbohydrate Polymers,2009,78(4):731-737.
APA	张俊平,汪琴,&王爱勤.(2009).Preparation and characterization of a novel pH sensitive chitosan-g-poly (acrylic acid)/attapulgite/sodium alginate composite hydrogel bead for controlled release of diclofenac sodium.Carbohydrate Polymers,78(4),731-737.
MLA	张俊平,et al."Preparation and characterization of a novel pH sensitive chitosan-g-poly (acrylic acid)/attapulgite/sodium alginate composite hydrogel bead for controlled release of diclofenac sodium".Carbohydrate Polymers 78.4(2009):731-737.