A compatibility assay of ursolic acid and foodborne microbial exopolysaccharides by antioxidant power and anti-proliferative properties in hepatocarcinoma cells

CORC > 天津工业生物技术研究所 > 功能糖与天然活性物质研究组孙媛霞 > 期刊论文

	A compatibility assay of ursolic acid and foodborne microbial exopolysaccharides by antioxidant power and anti-proliferative properties in hepatocarcinoma cells
	Liu, Ling 1; Wu, Junhua 1; Zhang, Jinlu 1; Li, Zhenjing 1; Wang, Changlu 1; Chen, Mianhua 1; Wang, Yurong 1; Sun, Yuanxia 2; Wang, Likui 3; Luo, Cheng 1
刊名	JOURNAL OF FOOD AGRICULTURE & ENVIRONMENT
	2012-04-01
卷号	10 期号:2 页码:111-114
关键词	Exopolysaccharide (EPS) ursolic acid (VA) anti-proliferation antioxidants MTT assay synergy
英文摘要	Oxidation is a chemical reaction that transfers electrons from a substance to an oxidizing agent, which produces harmful free radicals. However, natural antioxidants possess antioxidative properties and exogenous antioxidants are normally capable of inhibiting the oxidation in an organism. The synergy of different antioxidants would reverse the oxidation to a greater extent compared with a single antioxidant. We analyzed ursolic acid (UA) together with foodborne phosphate-containing viili exopolysaccharides (EPS) for antioxidant activities, and anti-proliferation properties of cancer cells. The strong antioxidant capacity of UA was observed at concentrations of 100 mu g/ml in ferric reducing antioxidant power test, where mild synergy with viili EPS was visible. Interestingly viili EPS had as strong antioxidative power as UA for the free radical scavenging activity in Fenton assay. The 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-tetrazolium bromide (MTT) assay with hepatoma HepG2 cells, the mild, but significant anti-proliferation by UA and EPS was seen at concentration of 200 mu g/ml, a synergic inhibition were particularly seen at 12.5 mu g/ml with a ratio of 3:2 EPS and UA. The senescence of HepG2 cancer cells after the combined treatment of UA and viili EPS at 12.5 mu g/ml were observed. These data indicated that UA is compatible with North European diets together with potential antioxidative and anti-proliferation complement modulating activities.
WOS标题词	Science & Technology ; Life Sciences & Biomedicine
类目[WOS]	Food Science & Technology
研究领域[WOS]	Food Science & Technology
关键词[WOS]	MESENTEROIDES SSP CREMORIS ; VIILI ; CYCLOOXYGENASE-2 ; POLYSACCHARIDES ; SUPPRESSION ; PROBIOTICS ; SBT-0495 ; SYSTEM ; MILK
收录类别	SCI
语种	英语
WOS记录号	WOS:000304335900017
公开日期	2012-08-29
内容类型	期刊论文
源URL	[http://localhost/handle/0/258]
专题	天津工业生物技术研究所_功能糖与天然活性物质研究组孙媛霞 _期刊论文
作者单位	1.Tianjin Univ Sci & Technol, Key Lab Food Nutr & Safely, Minist Educ, Sch Food Engn & Biotechnol, Tianjin 300457, Peoples R China 2.Chinese Acad Sci, Tianjin Inst Ind Biotechnol, Tianjin 300457, Peoples R China 3.Capital Med Univ, Beijing Friendship Hosp, Beijing 100050, Peoples R China
推荐引用方式 GB/T 7714	Liu, Ling,Wu, Junhua,Zhang, Jinlu,et al. A compatibility assay of ursolic acid and foodborne microbial exopolysaccharides by antioxidant power and anti-proliferative properties in hepatocarcinoma cells[J]. JOURNAL OF FOOD AGRICULTURE & ENVIRONMENT,2012,10(2):111-114.
APA	Liu, Ling.,Wu, Junhua.,Zhang, Jinlu.,Li, Zhenjing.,Wang, Changlu.,...&Luo, Cheng.(2012).A compatibility assay of ursolic acid and foodborne microbial exopolysaccharides by antioxidant power and anti-proliferative properties in hepatocarcinoma cells.JOURNAL OF FOOD AGRICULTURE & ENVIRONMENT,10(2),111-114.
MLA	Liu, Ling,et al."A compatibility assay of ursolic acid and foodborne microbial exopolysaccharides by antioxidant power and anti-proliferative properties in hepatocarcinoma cells".JOURNAL OF FOOD AGRICULTURE & ENVIRONMENT 10.2(2012):111-114.