Molecular scaffold of a new pokeweed antifungal peptide deduced by H-1 nuclear magnetic resonance | |
Gao, GH; Liu, W; Dai, JX; Wang, JF; Hu, Z; Zhang, Y![]() | |
刊名 | INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2001-12-10 | |
卷号 | 29期号:4-5页码:251-258 |
关键词 | antifungal peptides secondary structure cysteine pairing knottin-like peptide |
ISSN号 | 0141-8130 |
英文摘要 | The antifungal peptide from seeds of Phytolacca Americana (Pokeweed), designated PAFP-S hereinafter, is a recently found cationic peptide which consists of 38 amino acid residues and exihibites a broad spectrum of antifungal activity, including inhibition of certain saprophytic fungi and some plant pathogens. The secondary structure and three cysteine pairings have been investigated by H-1 NMR analysis. The results show that the molecular scaffold of PAFP-S features a triple-stranded antiparallel beta -sheet knotted by a typical disulfide bridge motif, which characterizes the knottin fold. CD spectroscopy indicates a high stability of the molecule in solution. Therefore, PAFP-S should be a new member of the knottin structural family and the first antifungal peptide that adopts the knottin-like fold. (C) 2001 Elsevier Science B.V. All rights reserved. |
学科主题 | Biochemistry & Molecular Biology |
类目[WOS] | Biochemistry & Molecular Biology |
研究领域[WOS] | Biochemistry & Molecular Biology |
关键词[WOS] | OMEGA-CONOTOXIN GVIA ; ALPHA-AMYLASE INHIBITOR ; ANTIMICROBIAL PEPTIDES ; PROTEINS ; BINDING ; SEEDS ; ASSIGNMENT ; AMARANTH ; TOXINS |
收录类别 | SCI |
语种 | 英语 |
WOS记录号 | WOS:000172670700005 |
公开日期 | 2012-07-24 |
内容类型 | 期刊论文 |
源URL | [http://ir.kib.ac.cn/handle/151853/14227] ![]() |
专题 | 昆明植物研究所_离退休 |
作者单位 | 1.Acad Sinica, Inst Biophys, Natl Lab Biomacromol, Beijing 100101, Peoples R China 2.Acad Sinica, Inst Biophys, Lab Mol Biophys, Beijing 100101, Peoples R China 3.Chinese Acad Sci, Kunming Inst Bot, Kunming 650204, Peoples R China |
推荐引用方式 GB/T 7714 | Gao, GH,Liu, W,Dai, JX,et al. Molecular scaffold of a new pokeweed antifungal peptide deduced by H-1 nuclear magnetic resonance[J]. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,2001,29(4-5):251-258. |
APA | Gao, GH.,Liu, W.,Dai, JX.,Wang, JF.,Hu, Z.,...&Wang, DC.(2001).Molecular scaffold of a new pokeweed antifungal peptide deduced by H-1 nuclear magnetic resonance.INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,29(4-5),251-258. |
MLA | Gao, GH,et al."Molecular scaffold of a new pokeweed antifungal peptide deduced by H-1 nuclear magnetic resonance".INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES 29.4-5(2001):251-258. |
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