Chitosan Oligosaccharides Protect Human Monocytes U937 from LPS-induced Inflammatory Damage through Blockade p38 MAPK Phosphorylation and Increasing O-GlcNAcylation of Proteins | |
Li Y(李昱) ; Peng Q(彭强) ; Xu QS(许青松) ; Du YG(杜昱光) | |
2011 | |
会议名称 | the 3rd asian communications of glycobiology and glycotechnology |
会议日期 | 2011-10-27 |
会议地点 | 上海 |
其他题名 | 壳寡糖通过阻断p38 mapk磷酸化增加蛋白o-glcnac修饰保护人单核细胞u937遭受lps诱导的炎症损伤 |
页码 | 69-0 |
通讯作者 | yuguangdu |
中文摘要 | to investigate the effects of chitosan oligosaccharides(cos) with different degree of polymerization(dp) on lps-induced inflammation, u937 human monocytes were cultured with dp2-8(cos-a) and dp7-15(cos-b) respectively, which were prepared by our group. the results showed that both kinds of cos demonstrated obviously anti-inflammatory effects against lps-induced over-expression of tnf-α and il-8. signal transduction studies indicated cos-a and cos-b efficiently down-regulated lps-induced the phosphorylation of p38 mapk. in several documented instances, phosphorylation and o-glcnac modification are reciprocal, occurring at the same or adjacent hydroxyl moieties. in this study, we also find cos-a and cos -b could significantly increase o-glcnac modification of proteins in lps-induced u937 monocytes. finally, we postulate that cos-a and cos-b may have anti-inflammatory effects via suppression of the expression levels of tnf-α and il-8, regulated by p38 mapk pathways and o-glcnacylation of proteins. |
合作状况 | 墙报 |
会议主办者 | 中国科学院上海有机化学所 |
会议录 | asian communications of glycobiology and glycotechnology
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会议录出版者 | 待补充 |
会议录出版地 | 待补充 |
学科主题 | 生物化学 |
内容类型 | 会议论文 |
源URL | [http://159.226.238.44/handle/321008/116085] ![]() |
专题 | 大连化学物理研究所_中国科学院大连化学物理研究所 |
推荐引用方式 GB/T 7714 | Li Y,Peng Q,Xu QS,et al. Chitosan Oligosaccharides Protect Human Monocytes U937 from LPS-induced Inflammatory Damage through Blockade p38 MAPK Phosphorylation and Increasing O-GlcNAcylation of Proteins[C]. 见:the 3rd asian communications of glycobiology and glycotechnology. 上海. 2011-10-27. |
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