Chitosan Oligosaccharides Protect Human Monocytes U937 from LPS-induced Inflammatory Damage through Blockade p38 MAPK Phosphorylation and Increasing O-GlcNAcylation of Proteins

	Chitosan Oligosaccharides Protect Human Monocytes U937 from LPS-induced Inflammatory Damage through Blockade p38 MAPK Phosphorylation and Increasing O-GlcNAcylation of Proteins
	Li Y(李昱) ; Peng Q(彭强) ; Xu QS(许青松) ; Du YG(杜昱光)
	2011
会议名称	the 3rd asian communications of glycobiology and glycotechnology
会议日期	2011-10-27
会议地点	上海
其他题名	壳寡糖通过阻断p38 mapk磷酸化增加蛋白o-glcnac修饰保护人单核细胞u937遭受lps诱导的炎症损伤
页码	69-0
通讯作者	yuguangdu
中文摘要	to investigate the effects of chitosan oligosaccharides(cos) with different degree of polymerization(dp) on lps-induced inflammation, u937 human monocytes were cultured with dp2-8(cos-a) and dp7-15(cos-b) respectively, which were prepared by our group. the results showed that both kinds of cos demonstrated obviously anti-inflammatory effects against lps-induced over-expression of tnf-α and il-8. signal transduction studies indicated cos-a and cos-b efficiently down-regulated lps-induced the phosphorylation of p38 mapk. in several documented instances, phosphorylation and o-glcnac modification are reciprocal, occurring at the same or adjacent hydroxyl moieties. in this study, we also find cos-a and cos -b could significantly increase o-glcnac modification of proteins in lps-induced u937 monocytes. finally, we postulate that cos-a and cos-b may have anti-inflammatory effects via suppression of the expression levels of tnf-α and il-8, regulated by p38 mapk pathways and o-glcnacylation of proteins.
合作状况	墙报
会议主办者	中国科学院上海有机化学所
会议录	asian communications of glycobiology and glycotechnology
会议录出版者	待补充
会议录出版地	待补充
学科主题	生物化学
内容类型	会议论文
源URL	[http://159.226.238.44/handle/321008/116085]
专题	大连化学物理研究所_中国科学院大连化学物理研究所
推荐引用方式 GB/T 7714	Li Y,Peng Q,Xu QS,et al. Chitosan Oligosaccharides Protect Human Monocytes U937 from LPS-induced Inflammatory Damage through Blockade p38 MAPK Phosphorylation and Increasing O-GlcNAcylation of Proteins[C]. 见:the 3rd asian communications of glycobiology and glycotechnology. 上海. 2011-10-27.