C5-Hydroxylation of liquiritigenin is catalyzed selectively by CYP1A2

	C5-Hydroxylation of liquiritigenin is catalyzed selectively by CYP1A2
	Wang, Ao-Xue 2; Hu, Ying 3; Liu, Hui-Xin 1; Qi, Xiao-Yi 2; Liu, Yong 3; Tu, Cai-Xia 2; Yang, Ling 3
刊名	xenobiotica
	2011-05-01
卷号	41 期号:5 页码:349-357
关键词	Liquiritigenin cytochrome P450 human liver microsomes metabolism
ISSN号	待补充
通讯作者	hui-xinliu
产权排序	2,2
中文摘要	c5-hydroxylation of liquiritigenin is catalyzed selectively by cyp1a2
英文摘要	1. liquiritigenin (7,4'-dihydroxyflavone), the primary active component of a traditional chinese medicine glycyrrhizae radix, has a wide range of pharmacological activities. six oxidative metabolites of liquiritigenin (7,3',4'-trihydroxyflavone, a hydroxyl quinine metabolite, two a-ring dihydroxymetabolites, 7,4'-dihydroxyflavone, and 7-hydroxychromone) have been detected in rat liver microsomes (rlms), and one cyp3a4-catalyzed metabolite (7,4'-dihydroxyflavone) has been identified in human liver microsomes (hlms) recently.
学科主题	物理化学
WOS标题词	science & technology ; life sciences & biomedicine
类目[WOS]	pharmacology & pharmacy ; toxicology
研究领域[WOS]	pharmacology & pharmacy ; toxicology
关键词[WOS]	human liver cytochrome-p450 ; glycyrrhizae-radix extract ; in-vitro ; endometrial carcinogenesis ; sinofranchetia-chinensis ; metabolic pathways ; microsomes ; rat ; inhibition ; licorice
收录类别	SCI
语种	英语
WOS记录号	WOS:000289432200001
公开日期	2012-07-09
内容类型	期刊论文
源URL	[http://159.226.238.44/handle/321008/115814]
专题	大连化学物理研究所_中国科学院大连化学物理研究所
作者单位	1.Univ Kansas, Med Ctr, Kansas City, KS 66103 USA 2.Dalian Med Univ, Affiliated Hosp 2, Dalian, Peoples R China 3.Chinese Acad Sci, Dalian Inst Chem Phys, Lab Pharmaceut Resource Discovery, Dalian, Peoples R China
推荐引用方式 GB/T 7714	Wang, Ao-Xue,Hu, Ying,Liu, Hui-Xin,et al. C5-Hydroxylation of liquiritigenin is catalyzed selectively by CYP1A2[J]. xenobiotica,2011,41(5):349-357.
APA	Wang, Ao-Xue.,Hu, Ying.,Liu, Hui-Xin.,Qi, Xiao-Yi.,Liu, Yong.,...&Yang, Ling.(2011).C5-Hydroxylation of liquiritigenin is catalyzed selectively by CYP1A2.xenobiotica,41(5),349-357.
MLA	Wang, Ao-Xue,et al."C5-Hydroxylation of liquiritigenin is catalyzed selectively by CYP1A2".xenobiotica 41.5(2011):349-357.