Promoting the formation and stabilization of human telomeric G-quadruplex DNA, inhibition of telomerase and cytotoxicity by phenanthroline derivatives

	Promoting the formation and stabilization of human telomeric G-quadruplex DNA, inhibition of telomerase and cytotoxicity by phenanthroline derivatives
	Wang, Lihua 1; Wen, Ye 1; Liu, Jie 1; Zhou, Jun 2; Li, Can 2; Wei, Chunying 1
刊名	organic & biomolecular chemistry
	2011
卷号	9 期号:8 页码:2648-2653
ISSN号	待补充
通讯作者	魏春英
产权排序	2,4
中文摘要	promoting the formation and stabilization of human telomeric g-quadruplex dna, inhibition of telomerase and cytotoxicity by phenanthroline derivatives
英文摘要	four new di-substituted phenanthroline-based compounds a-d have been designed and prepared, and they have been shown to induce the formation of anti-parallel structure of human telomeric g-quadruplex dna by cd spectra. fret assay indicates that the melting temperature increases (delta t-m values) of g-quadruplex in buffer (ph 7.4) containing 100 mm nacl are 31.6, 34.6, 17.8 and 32.6 degrees c for the compounds (1.0 mu m) a, b, c and d, respectively. competitive fret assay shows that the four compounds exhibit a high g-quadruplex dna selectivity over duplex dna. three of the compounds are the potent telomerase inhibitors and hela cell proliferation inhibitors.
学科主题	物理化学
WOS标题词	science & technology ; physical sciences
类目[WOS]	chemistry, organic
研究领域[WOS]	chemistry
关键词[WOS]	intramolecular g-quadruplex ; ligands ; complexes ; recognition ; binding ; protocol ; hybrid ; forms
收录类别	SCI ; IC
语种	英语
WOS记录号	WOS:000288904500013
公开日期	2012-07-09
内容类型	期刊论文
源URL	[http://159.226.238.44/handle/321008/115744]
专题	大连化学物理研究所_中国科学院大连化学物理研究所
作者单位	1.Shanxi Univ, Inst Mol Sci, Key Lab Chem Biol & Mol Engn, Minist Educ, Taiyuan 030006, Peoples R China 2.Chinese Acad Sci, Dalian Inst Chem Phys, BState Key Lab Catalysis, Dalian 116023, Peoples R China
推荐引用方式 GB/T 7714	Wang, Lihua,Wen, Ye,Liu, Jie,et al. Promoting the formation and stabilization of human telomeric G-quadruplex DNA, inhibition of telomerase and cytotoxicity by phenanthroline derivatives[J]. organic & biomolecular chemistry,2011,9(8):2648-2653.
APA	Wang, Lihua,Wen, Ye,Liu, Jie,Zhou, Jun,Li, Can,&Wei, Chunying.(2011).Promoting the formation and stabilization of human telomeric G-quadruplex DNA, inhibition of telomerase and cytotoxicity by phenanthroline derivatives.organic & biomolecular chemistry,9(8),2648-2653.
MLA	Wang, Lihua,et al."Promoting the formation and stabilization of human telomeric G-quadruplex DNA, inhibition of telomerase and cytotoxicity by phenanthroline derivatives".organic & biomolecular chemistry 9.8(2011):2648-2653.