Plasma and Liver Lipidomics Response to an Intervention of Rimonabant in ApoE*3Leiden.CETP Transgenic Mice

	*Plasma and Liver Lipidomics Response to an Intervention of Rimonabant in ApoE3Leiden.CETP Transgenic Mice**
	Hu, Chunxiu 1,2; Wei, Heng 3,6; van den Hoek, Anita M.5; Wang, Mei 3,4; van der Heijden, Rob 2; Spijksma, Gerwin 2; Reijmers, Theo H.2; Bouwman, Jildau 6,7; Wopereis, Suzan 6; Havekes, Louis M.5
刊名	plos one
	2011-05-17
卷号	6 期号:5 页码:e19423
ISSN号	待补充
通讯作者	许国旺 ; vandergreefjan
产权排序	1,1
中文摘要	plasma and liver lipidomics response to an intervention of rimonabant in apoe*3leiden.cetp transgenic mice
英文摘要	background: lipids are known to play crucial roles in the development of life-style related risk factors such as obesity, dyslipoproteinemia, hypertension and diabetes. the first selective cannabinoid-1 receptor blocker rimonabant, an anorectic anti-obesity drug, was frequently used in conjunction with diet and exercise for patients with a body mass index greater than 30 kg/m(2) with associated risk factors such as type ii diabetes and dyslipidaemia in the past. less is known about the impact of this drug on the regulation of lipid metabolism in plasma and liver in the early stage of obesity.
学科主题	物理化学
WOS标题词	science & technology
类目[WOS]	multidisciplinary sciences
研究领域[WOS]	science & technology - other topics
关键词[WOS]	cholesteryl ester transfer ; cardiovascular risk-factors ; increases hdl-cholesterol ; cb1 receptor antagonist ; free fatty-acids ; transfer protein ; aggravates atherosclerosis ; overweight patients ; metabolic syndrome ; hepatic steatosis
收录类别	SCI
语种	英语
WOS记录号	WOS:000290657500004
公开日期	2012-07-09
内容类型	期刊论文
源URL	[http://159.226.238.44/handle/321008/115681]
专题	大连化学物理研究所_中国科学院大连化学物理研究所
作者单位	1.Chinese Acad Sci, Dalian Inst Chem Phys, CAS Key Lab Separat Sci Analyt Chem, Dalian, Peoples R China 2.Leiden Univ, Leiden Amsterdam Ctr Drug Res, Div Analyt Biosci, Leiden, Netherlands 3.Sino Dutch Ctr Prevent & Personalized Med, Zeist, Netherlands 4.SU BioMed, Zeist, Netherlands 5.TNO, Gaubius Lab, Leiden, Netherlands 6.TNO, Dept Earth Environm & Life Sci, NL-3700 AJ Zeist, Netherlands 7.Leiden Univ, Leiden Amsterdam Ctr Drug Res, Netherlands Metab Ctr, Leiden, Netherlands
推荐引用方式 GB/T 7714	Hu, Chunxiu,Wei, Heng,van den Hoek, Anita M.,et al. Plasma and Liver Lipidomics Response to an Intervention of Rimonabant in ApoE*3Leiden.CETP Transgenic Mice[J]. plos one,2011,6(5):e19423.
APA	Hu, Chunxiu.,Wei, Heng.,van den Hoek, Anita M..,Wang, Mei.,van der Heijden, Rob.,...&van der Greef, Jan.(2011).Plasma and Liver Lipidomics Response to an Intervention of Rimonabant in ApoE*3Leiden.CETP Transgenic Mice.plos one,6(5),e19423.
MLA	Hu, Chunxiu,et al."Plasma and Liver Lipidomics Response to an Intervention of Rimonabant in ApoE*3Leiden.CETP Transgenic Mice".plos one 6.5(2011):e19423.