A cytotoxic 4 alpha-methyl steroid from the aerial parts of Cimicifuga foetida L

CORC > 昆明植物研究所 > 中国科学院昆明植物研究所 > 植物化学与西部植物资源持续利用国家重点实验室

	A cytotoxic 4 alpha-methyl steroid from the aerial parts of Cimicifuga foetida L
	Nian, Yin1,2 ; Wang, Hai-Yan 1,2; Su, Jia 1,2; Zhou, Lin 1; Qiu, Ming-Hua1
刊名	FITOTERAPIA
	2012-03-01
卷号	83 期号:2 页码:293-297
关键词	Cimicifuga foetida 4 alpha-methyl steroid Cytotoxicity Cimisterol A
ISSN号	0367-326X
通讯作者	Qiu, MH (reprint author), Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Peoples R China, mhchiu@mail.kib.ac.cn
英文摘要	A new 4 alpha-methyl sterol, cimisterol A (1), together with five known compounds (2-6), were isolated from the aerial parts of Cimicifuga foetida L The new compound's structure was determined with the help of extensive 1D and 2D NMR spectroscopy. Compound 1 exhibited broad-spectrum and potent cytotoxic activities against human HL-60, Jurkat, K562, U937, HepG-2, and SGC-7091 cell lines, with IC50 values of 7.23, 2.89, 6.88, 3.38, 4.21, and 4.89 mu M, respectively. Compound 3 showed moderate to weak activities to all cell lines, except for SGC-7091, having 1050 values ranging from 13.37 to 17.72 mu M. This is the first time a cytotoxic 4 alpha-methyl sterol constituent was discovered from Cimicifuga spp. (C) 2011 Elsevier B.V. All rights reserved,
学科主题	Chemistry, Medicinal; Pharmacology & Pharmacy
类目[WOS]	Chemistry, Medicinal ; Pharmacology & Pharmacy
研究领域[WOS]	Pharmacology & Pharmacy
关键词[WOS]	PERFORMANCE LIQUID-CHROMATOGRAPHY ; LIGHT-SCATTERING DETECTION ; BLACK COHOSH PRODUCTS ; EUPHORBIA-CHAMAESYCE ; SEQUENCE VARIATION ; ACTAEA-RACEMOSA ; WHOLE HERB ; TRITERPENOIDS ; CONSTITUENTS ; IDENTIFICATION
收录类别	SCI
资助信息	National Natural Science Foundation of China[30772636]; CAS[KSCX2-YW-G-038, KSCX2-YW-R-194, KSCX2-YW-R-29, KSCX2-EW-R-15, KZCX2-XB2-15-03]; Foundation of State Key Laboratory of Phytochemistry and Plant Resources in West China[P2008-ZZ05, P2010-ZZ14]
语种	英语
WOS记录号	WOS:000300817000006
公开日期	2012-06-07
内容类型	期刊论文
源URL	[http://ir.kib.ac.cn/handle/151853/10415]
专题	昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室
作者单位	1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Peoples R China 2.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China
推荐引用方式 GB/T 7714	Nian, Yin,Wang, Hai-Yan,Su, Jia,et al. A cytotoxic 4 alpha-methyl steroid from the aerial parts of Cimicifuga foetida L[J]. FITOTERAPIA,2012,83(2):293-297.
APA	Nian, Yin,Wang, Hai-Yan,Su, Jia,Zhou, Lin,&Qiu, Ming-Hua.(2012).A cytotoxic 4 alpha-methyl steroid from the aerial parts of Cimicifuga foetida L.FITOTERAPIA,83(2),293-297.
MLA	Nian, Yin,et al."A cytotoxic 4 alpha-methyl steroid from the aerial parts of Cimicifuga foetida L".FITOTERAPIA 83.2(2012):293-297.