Colorimetric and near-infrared fluorescence turn-on molecular probe for direct and highly selective detection of cysteine in human plasma

	Colorimetric and near-infrared fluorescence turn-on molecular probe for direct and highly selective detection of cysteine in human plasma
	Hao WH ; McBride A ; McBride S ; Gao JP ; Wang ZY
刊名	journal of materials chemistry
	2011
卷号	21 期号:4 页码:1040-1048
关键词	PERFORMANCE LIQUID-CHROMATOGRAPHY OPTICALLY NONLINEAR ADDUCTS THIOL-CONTAINING COMPOUNDS LANGMUIR-BLODGETT-FILMS TOTAL HOMOCYSTEINE AMINO-ACIDS DERIVATIZATION GLUTATHIONE SENSOR ALDEHYDE
ISSN号	0959-9428
通讯作者	wang zy
中文摘要	a highly efficient colorimetric and fluorescence turn-on molecular probe for sensitive and selective detection of biologically important cysteine (cys) in human plasma is demonstrated using a new zwitterionic dye (m1). the sensing mechanism involves release of the blue-colored and fluorescent m1 from its non-fluorescent, pale-yellow copper complex (m1-cu) upon exposure to cys. the new dye has the desired properties suitable for bio-sensing applications, such as distinct blue color, near-infrared (nir) fluorescence at the wavelength of 875 nm, a large stokes shift (195 nm), high solubility and stability. this new probe shows both colorimetric and fluorescent responses specifically to cys over other naturally occurring amino acids, amines and some bioactive thiols and allows for detection of cys in aqueous solution with a low detection limit of 4.07 x 10(-6) m and in human plasma at the physiologically relevant levels.
收录类别	SCI收录期刊论文
语种	英语
WOS记录号	WOS:000286110400017
公开日期	2012-06-12
内容类型	期刊论文
源URL	[http://ir.ciac.jl.cn/handle/322003/45118]
专题	长春应用化学研究所_长春应用化学研究所知识产出_期刊论文
推荐引用方式 GB/T 7714	Hao WH,McBride A,McBride S,et al. Colorimetric and near-infrared fluorescence turn-on molecular probe for direct and highly selective detection of cysteine in human plasma[J]. journal of materials chemistry,2011,21(4):1040-1048.
APA	Hao WH,McBride A,McBride S,Gao JP,&Wang ZY.(2011).Colorimetric and near-infrared fluorescence turn-on molecular probe for direct and highly selective detection of cysteine in human plasma.journal of materials chemistry,21(4),1040-1048.
MLA	Hao WH,et al."Colorimetric and near-infrared fluorescence turn-on molecular probe for direct and highly selective detection of cysteine in human plasma".journal of materials chemistry 21.4(2011):1040-1048.