Anti-tumor Activity of Biodegradable Polymer-Paclitaxel Conjugate Micelles on Lewis Lung Cancer Mice Models

	Anti-tumor Activity of Biodegradable Polymer-Paclitaxel Conjugate Micelles on Lewis Lung Cancer Mice Models
	Wan YH ; Zheng YH ; Song XF ; Hu XL ; Liu S ; Tong T ; Jing XB
刊名	journal of biomaterials science-polymer edition
	2011
卷号	22 期号:9 页码:1131-1146
关键词	AMPHIPHILIC BLOCK-COPOLYMERS ACID) TRIBLOCK COPOLYMER PH-CONTROLLED ACTIVATION DRUG-DELIVERY FOLATE-RECEPTOR MICELLIZATION CYTOTOXICITY APOPTOSIS AGENTS TAXOL
ISSN号	0920-5063
通讯作者	jing xb
中文摘要	two kinds of paclitaxel (ptx) conjugate nanomicelles were prepared for cell apoptosis and anti-tumor activity evaluation on lewis lung cancer mice models. one (ptx micelles) was prepared by self-assembling the ptx-conjugate co-polymer, poly(ethylene glycol)-b-poly(l-lactide-co-2-methyl-2-carboxyl-propylene carbonate/ptx), and the other (fa-ptx micelles) was by co-assembling a mixture of the folic acid (fa)-carrying co-polymer poly(ethylene glycol)-b-poly(l-lactide-co-2,2-dihydroxylmethyl-propylene carbonate/fa) (peg-b-p(la-co-dhp/fa)), and the ptx-conjugate co-polymer. at 7 and 14 days after tail intravenous injection, the mice were killed. the inhibition rates of tumor growth for ptx and fa-ptx micelles were 50 and 90%, respectively, on the day 7, and 33 and 71%, respectively, on the day 14 after drug injection. flow cytometry analysis showed that the cell apoptosis rates were 43, 54 and 72% for the control group, ptx micelles group and fa-ptx micelles group, respectively, on the day 7, and 16, 25 and 42 on the day 14. with the tunel assay, the grey values of ptx micelles and fa-ptx micelles groups were determined to be 61-62% and 43-44%, of that of the control group, on day 7 or day 14, respectively. therefore, the ptx micelles and the fa-ptx composite micelles significantly inhibited the subcutaneously inoculated lewis lung cancer and effectively induced the cell apoptosis, and the fa-ptx composite micelles displayed a better efficacy than the ptx-micelles, implying the contribution of the folate-mediated targeting and endocytosis effect. (c) koninklijke brill nv, leiden, 2011
收录类别	SCI收录期刊论文
语种	英语
WOS记录号	WOS:000288135600002
公开日期	2012-06-12
内容类型	期刊论文
源URL	[http://ir.ciac.jl.cn/handle/322003/45117]
专题	长春应用化学研究所_长春应用化学研究所知识产出_期刊论文
推荐引用方式 GB/T 7714	Wan YH,Zheng YH,Song XF,et al. Anti-tumor Activity of Biodegradable Polymer-Paclitaxel Conjugate Micelles on Lewis Lung Cancer Mice Models[J]. journal of biomaterials science-polymer edition,2011,22(9):1131-1146.
APA	Wan YH.,Zheng YH.,Song XF.,Hu XL.,Liu S.,...&Jing XB.(2011).Anti-tumor Activity of Biodegradable Polymer-Paclitaxel Conjugate Micelles on Lewis Lung Cancer Mice Models.journal of biomaterials science-polymer edition,22(9),1131-1146.
MLA	Wan YH,et al."Anti-tumor Activity of Biodegradable Polymer-Paclitaxel Conjugate Micelles on Lewis Lung Cancer Mice Models".journal of biomaterials science-polymer edition 22.9(2011):1131-1146.